The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012.
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Cites background from "The global incidence of lip, oral c..."
...The squamous cell carcinoma is the most common pathological type of HNSC.(2) Local recurrence, cervical nodemetastasis, and treatment failure causedby resistance to conventional chemotherapy are the leading causes of death in patients with advanced head and neck squamous cell carcinoma (HNSC)....
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...The stratified analysis revealed that the prognosis value of ICI scores was independent of TMB in HNSC....
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...Evaluating the ICI patterns of a larger cohort of samples will extend our understanding ofTME, and it may provide directions to the current research investigations on immunotherapeutic strategies for HNSC....
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...The early clinical trials of immunotherapy have demonstrated its high efficacy in tumorigenic growth eradication and improvement in the quality of life in patients with advanced HNSC. Due to these factors, the US Food Drug Administration and the European Medicines Agency have approved pembrolizumab as the front-line treatment in subjects with unresectable recurrent/metastatic HNSC.3 A signifi- 304 Molecular Therapy: Nucleic Acids Vol. 22 December 2020 cant limitation of immunotherapy is that only a minority of patients have benefitted from it....
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...Taking into account the contraindicatory prognostic value of TMB and ICI scores, we next evaluated the synergistic effect of these scores in prognostic stratification of HNSC. Stratified survival analysis revealed that the TMB status did not interfere with ICI scores-based predictions....
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References
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"The global incidence of lip, oral c..." refers background or result in this paper
...TNM system in particular requiring more detailed topological information.(11,77,124) Finally, with respect to the CI5-X data, determining the topographical codes for lip, oral cavity, and pharyngeal cancers was a complex task....
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...S1 to S4 and Tables S1 to S11 in the online supporting information).(11) In a few instances where registry data within a country were sparse, registry data from neighboring countries were combined (see Table S12 in the online supporting information)....
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3,075 citations
"The global incidence of lip, oral c..." refers background in this paper
...ranging from 46% to 61% when a patient is treated with chemotherapy and 40% to 72% when patients are treated with chemotherapy and radiotherapy.(80) However, progno-...
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...much better survival rates than those with stage III and IV cancers.(80) Prognosis may depend on the pathology type of nasopharyngeal cancer, with those classified as World...
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