Journal ArticleDOI
The global prevalence of dementia: A systematic review and metaanalysis
Martin Prince,Renata Bryce,Emiliano Albanese,Emiliano Albanese,Anders Wimo,Wagner Silva Ribeiro,Wagner Silva Ribeiro,Cleusa P. Ferri,Cleusa P. Ferri +8 more
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TLDR
A reappraisal of global prevalence and numbers is due, given the significant implications for social and public policy and planning.Abstract:
Background The evidence base on the prevalence of dementia is expanding rapidly, particularly in countries with low and middle incomes. A reappraisal of global prevalence and numbers is due, given the significant implications for social and public policy and planning. Methods In this study we provide a systematic review of the global literature on the prevalence of dementia (1980–2009) and metaanalysis to estimate the prevalence and numbers of those affected, aged ≥60 years in 21 Global Burden of Disease regions. Results Age-standardized prevalence for those aged ≥60 years varied in a narrow band, 5%–7% in most world regions, with a higher prevalence in Latin America (8.5%), and a distinctively lower prevalence in the four sub-Saharan African regions (2%–4%). It was estimated that 35.6 million people lived with dementia worldwide in 2010, with numbers expected to almost double every 20 years, to 65.7 million in 2030 and 115.4 million in 2050. In 2010, 58% of all people with dementia lived in countries with low or middle incomes, with this proportion anticipated to rise to 63% in 2030 and 71% in 2050. Conclusion The detailed estimates in this study constitute the best current basis for policymaking, planning, and allocation of health and welfare resources in dementia care. The age-specific prevalence of dementia varies little between world regions, and may converge further. Future projections of numbers of people with dementia may be modified substantially by preventive interventions (lowering incidence), improvements in treatment and care (prolonging survival), and disease-modifying interventions (preventing or slowing progression). All countries need to commission nationally representative surveys that are repeated regularly to monitor trends.read more
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Journal ArticleDOI
Dementia prevention, intervention, and care
Gill Livingston,Gill Livingston,Andrew Sommerlad,Vasiliki Orgeta,Sergi G. Costafreda,Sergi G. Costafreda,Jonathan Huntley,Jonathan Huntley,David Ames,Clive Ballard,Sube Banerjee,Alistair Burns,Jiska Cohen-Mansfield,Claudia Cooper,Claudia Cooper,Nick C. Fox,Laura N. Gitlin,Robert Howard,Robert Howard,Helen C. Kales,Eric B. Larson,Eric B. Larson,Karen Ritchie,Karen Ritchie,Kenneth Rockwood,Elizabeth L Sampson,Quincy M. Samus,Lon S. Schneider,Geir Selbæk,Geir Selbæk,Linda Teri,Naaheed Mukadam +31 more
TL;DR: The Lancet Commission on Dementia Prevention, Intervention, and Care met to consolidate the huge strides that have been made and the emerging knowledge as to what the authors should do to prevent and manage dementia.
Journal ArticleDOI
Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
Emma Nichols,Cassandra Szoeke,Stein Emil Vollset,Nooshin Abbasi,Foad Abd-Allah,Jemal Abdela,Miloud Taki Eddine Aichour,Rufus Akinyemi,Fares Alahdab,Solomon Weldegebreal Asgedom,Ashish Awasthi,Suzanne Barker-Collo,Bernhard T. Baune,Yannick Béjot,Abate Bekele Belachew,Derrick A Bennett,Belete Biadgo,Ali Bijani,Muhammad Shahdaat Bin Sayeed,Carol Brayne,David O. Carpenter,Félix Carvalho,Ferrán Catalá-López,Ester Cerin,Jee-Young Jasmine Choi,Anh Kim Dang,Meaza Girma Degefa,Shirin Djalalinia,Manisha Dubey,Eyasu Ejeta Duken,David Edvardsson,Matthias Endres,Sharareh Eskandarieh,André Faro,Farshad Farzadfar,Seyed-Mohammad Fereshtehnejad,Eduarda Fernandes,Irina Filip,Florian Fischer,Abadi Kahsu Gebre,Demeke Geremew,Maryam Ghasemi-Kasman,Elena V. Gnedovskaya,Rajeev Gupta,Vladimir Hachinski,Tekleberhan B. Hagos,Samer Hamidi,Graeme J. Hankey,Josep Maria Haro,Simon I. Hay,Seyed Sina Naghibi Irvani,Ravi Prakash Jha,Jost B. Jonas,Rizwan Kalani,André Karch,Amir Kasaeian,Yousef Khader,Ibrahim A Khalil,Ejaz Ahmad Khan,Tripti Khanna,Tawfik Ahmed Muthafer Khoja,Jagdish Khubchandani,Adnan Kisa,Katarzyna Kissimova-Skarbek,Mika Kivimäki,Ai Koyanagi,Kristopher J Krohn,Giancarlo Logroscino,Stefan Lorkowski,Marek Majdan,Reza Malekzadeh,Winfried März,João Massano,Getnet Mengistu,Atte Meretoja,Moslem Mohammadi,Maryam Mohammadi-Khanaposhtani,Ali H. Mokdad,Stefania Mondello,Ghobad Moradi,Gabriele Nagel,Mohsen Naghavi,Gurudatta Naik,Long H. Nguyen,Trang Huyen Nguyen,Yirga Legesse Nirayo,Molly R Nixon,Richard Ofori-Asenso,Felix Akpojene Ogbo,Andrew T Olagunju,Mayowa O. Owolabi,Songhomitra Panda-Jonas,Valéria Maria de Azeredo Passos,David M. Pereira,Gabriel David Pinilla-Monsalve,Michael A. Piradov,Constance D. Pond,Hossein Poustchi,Mostafa Qorbani,Amir Radfar,Robert C. Reiner,Stephen R. Robinson,Gholamreza Roshandel,Ali Rostami,Tom C. Russ,Perminder S. Sachdev,Hosein Safari,Saeid Safiri,Ramesh Sahathevan,Yahya Salimi,Maheswar Satpathy,Monika Sawhney,Mete Saylan,Sadaf G. Sepanlou,Azadeh Shafieesabet,Masood Ali Shaikh,Mohammad Ali Sahraian,Mika Shigematsu,Rahman Shiri,Ivy Shiue,João Pedro Silva,Mari Smith,Soheila Sobhani,Dan J. Stein,Rafael Tabarés-Seisdedos,Marcos Roberto Tovani-Palone,Bach Xuan Tran,Tung Thanh Tran,Amanuel Amanuel Tesfay Tsegay,Irfan Ullah,Narayanaswamy Venketasubramanian,Vasily Vlassov,Yuan-Pang Wang,Jordan Weiss,Ronny Westerman,Tissa Wijeratne,Grant M. A. Wyper,Yuichiro Yano,Ebrahim M Yimer,Naohiro Yonemoto,Mahmoud Yousefifard,Zoubida Zaidi,Zohreh Zare,Theo Vos,Valery L. Feigin,Christopher J L Murray +145 more
TL;DR: The first detailed analysis of the global prevalence, mortality, and overall burden of dementia as captured by the Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016 is presented, to highlight the most important messages for clinicians and neurologists.
Journal ArticleDOI
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
Iris E. Jansen,Jeanne E. Savage,Kyoko Watanabe,Julien Bryois,Dylan M. Williams,Stacy Steinberg,Julia Sealock,Ida K. Karlsson,Ida K. Karlsson,Sara Hägg,Lavinia Athanasiu,Lavinia Athanasiu,Nicola Voyle,Petroula Proitsi,Aree Witoelar,Sven Stringer,Dag Aarsland,Dag Aarsland,Ina S. Almdahl,Ina S. Almdahl,Ina S. Almdahl,Fred Andersen,Sverre Bergh,Francesco Bettella,Sigurbjorn Bjornsson,Anne Brækhus,Geir Bråthen,Christiaan de Leeuw,Rahul S. Desikan,Srdjan Djurovic,Srdjan Djurovic,Logan Dumitrescu,Tormod Fladby,Tormod Fladby,Timothy J. Hohman,Palmi V. Jonsson,Steven J. Kiddle,Arvid Rongve,Ingvild Saltvedt,Sigrid Botne Sando,Geir Selbæk,Maryam Shoai,Nathan G. Skene,Nathan G. Skene,Jon Snaedal,Eystein Stordal,Eystein Stordal,Ingun Ulstein,Yunpeng Wang,Linda R. White,John Hardy,Jens Hjerling-Leffler,Patrick F. Sullivan,Patrick F. Sullivan,Wiesje M. van der Flier,Richard Dobson,Lea K. Davis,Hreinn Stefansson,Kari Stefansson,Nancy L. Pedersen,Stephan Ripke,Stephan Ripke,Stephan Ripke,Ole A. Andreassen,Danielle Posthuma,Danielle Posthuma +65 more
TL;DR: A large genome-wide association study of clinically diagnosed AD and AD-by-proxy identifies new loci and functional pathways that contribute to AD risk and adds novel insights into the neurobiology of AD.
Journal ArticleDOI
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Bengt Winblad,Bengt Winblad,Philippe Amouyel,Sandrine Andrieu,Clive Ballard,Carol Brayne,Henry Brodaty,Angel Cedazo-Minguez,Bruno Dubois,David Edvardsson,David Edvardsson,Howard Feldman,Laura Fratiglioni,Giovanni B. Frisoni,Serge Gauthier,Jean Georges,Caroline Graff,Caroline Graff,Khalid Iqbal,Frank Jessen,Frank Jessen,Gunilla Johansson,Linus Jönsson,Miia Kivipelto,Miia Kivipelto,Martin Knapp,Francesca Mangialasche,René J. F. Melis,Agneta Nordberg,Agneta Nordberg,Marcel G. M. Olde Rikkert,Chengxuan Qiu,Thomas P. Sakmar,Thomas P. Sakmar,Philip Scheltens,Lon S. Schneider,Reisa A. Sperling,Lars O. Tjernberg,Gunhild Waldemar,Anders Wimo,Henrik Zetterberg,Henrik Zetterberg +41 more
TL;DR: This poster aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical and cognitive properties of Alzheimer's disease and other dementias.
Journal ArticleDOI
The worldwide economic impact of dementia 2010
TL;DR: This work aims to acquire an understanding of the societal costs of dementia and how they affect families, health and social care services, and governments to improve the lives of people with dementia and their caregivers.
References
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Journal ArticleDOI
Global prevalence of dementia: a Delphi consensus study
Cleusa P. Ferri,Martin Prince,Carol Brayne,Henry Brodaty,Laura Fratiglioni,Mary Ganguli,Kathleen S. Hall,Kazuo Hasegawa,Hugh C. Hendrie,Yueqin Huang,Anthony F. Jorm,Colin Mathers,Paulo Rossi Menezes,Elizabeth Rimmer,Marcia Scazufca +14 more
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Journal ArticleDOI
The projected effect of risk factor reduction on Alzheimer's disease prevalence
TL;DR: The aim of this Review was to summarise the evidence regarding seven potentially modifiable risk factors for AD: diabetes, midlife hypertension, mid life obesity, smoking, depression, cognitive inactivity or low educational attainment, and physical inactivity.
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Prevalence of dementia in the United States: the aging, demographics, and memory study.
Brenda L. Plassman,Kenneth M. Langa,Gwenith G. Fisher,Steven G. Heeringa,David R. Weir,Mary Beth Ofstedal,James R. Burke,Michael D. Hurd,Guy G. Potter,Willard L. Rodgers,David C. Steffens,Robert J. Willis,Robert B. Wallace +12 more
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Journal Article
Prevalence of dementia and major subtypes in Europe : A collaborative study of population-based cohorts
A. Lobo,Lenore J. Launer,Laura Fratiglioni,Kjeld Andersen,A. Di Carlo,Monique M.B. Breteler,John R. M. Copeland,J. F. Dartigues,Carol Jagger,J.M. Martinez-Lage,Hilkka Soininen,Albert Hofman +11 more
TL;DR: Dementia is more prevalent in women, and AD is the main contributor to the steep increase of prevalence with age, so a large variation across studies was observed, as well as a difference in prevalence between men and women that was age dependent.
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