The heat-shock response
TL;DR: A comparison of different Organisms and Stages of Development and Heat-Induced Lethality and Thermotolerance and the role of RNA Processing are presented.
Abstract: PERSPECTIVES AND SUMMARY . . . . . 1151 CHARACTERIZATION OF THE RESPONSE 1153 Comparison: Different Organisms and Stages of Development. ll53 The Proteins Induced by Heat ... . 1155 RNAs Induced by Heat 1167 OTHER INDUCTIONS OF HSPs 1168 Developmental Inductions .. . ... . . . . . . .. .. .. . ... ...... . .... . .. . . . 1168 Other Inducers 1 1 69 Is There a Common Mechanism? ........ ... 1170 GENOME ORGANIZATION 1172 REGULATION OF THE RESPONSE 1173 Transcription 1173 Translation . . . . .. ..... ......... .. . . .. .. .. .... . .. ...... . . . .. . . . . .. .. .. . .. .. .. . . . . . . . . . 1177 RNA Processing 1178 TOLERANCE TO HEAT AND OTHER FORMS OF STRESS . . . 1179 Heat-Induced Lethality and Thermotolerance . . . . . . . . . . . . . 1179 Phenocopies 1182 CONCLUDING REMARKS 1184
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TL;DR: Roles moleculaires des proteines de choc thermique dans le fonctionnement des organismes a des temperatures normales et suite a des chocs thermiques; differents genes impliques.
Abstract: Roles moleculaires des proteines de choc thermique dans le fonctionnement des organismes a des temperatures normales et suite a des chocs thermiques; differents genes impliques
5,100 citations
Cites background from "The heat-shock response"
...Usually, the acquisition of thermotolerance is also blocked (127, 134)....
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TL;DR: Folding and assembly of polypeptides in vivo involves other proteins, many of which belong to families that have been highly conserved during evolution.
Abstract: In the cell, as in vitro, the final conformation of a protein is determined by its amino-acid sequence. But whereas some isolated proteins can be denatured and refolded in vitro in the absence of other macromolecular cellular components, folding and assembly of polypeptides in vivo involves other proteins, many of which belong to families that have been highly conserved during evolution.
4,181 citations
TL;DR: This work discloses that expression of Hsps can occur in nature, all species have hsp genes but they vary in the patterns of their expression, and Hsp expression can be correlated with resistance to stress, and species' thresholds for HSP expression are correlated with levels of stress that they naturally undergo.
Abstract: Molecular chaperones, including the heat-shock proteins (Hsps), are a ubiquitous feature of cells in which these proteins cope with stress-induced denaturation of other proteins. Hsps have received the most attention in model organisms undergoing experimental stress in the laboratory, and the function of Hsps at the molecular and cellular level is becoming well understood in this context. A complementary focus is now emerging on the Hsps of both model and nonmodel organisms undergoing stress in nature, on the roles of Hsps in the stress physiology of whole multicellular eukaryotes and the tissues and organs they comprise, and on the ecological and evolutionary correlates of variation in Hsps and the genes that encode them. This focus discloses that (a) expression of Hsps can occur in nature, (b) all species have hsp genes but they vary in the patterns of their expression, (c) Hsp expression can be correlated with resistance to stress, and (d) species' thresholds for Hsp expression are correlated with levels of stress that they naturally undergo. These conclusions are now well established and may require little additional confirmation; many significant questions remain unanswered concerning both the mechanisms of Hsp-mediated stress tolerance at the organismal level and the evolutionary mechanisms that have diversified the hsp genes.
3,841 citations
Cites background from "The heat-shock response"
...whose expression is induced by heat and other stresses (1, 2), discoveries of the...
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TL;DR: The significance of Hsps and chaperones in abiotic stress responses in plants is summarized, and the co-operation among their different classes and their interactions with other stress-induced components are discussed.
2,309 citations
TL;DR: The Lon Protease, DnaK.T URNOVER of AB ERR ANT PROT EINS in E. COLI, and more.
Abstract: T URNOVER OF AB ERR ANT PROT EINS IN E. COLI . . . . . . . . . . . . . . . . . 445 The Lon Protease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 446 DnaK. DnaJ. GrpE. GroEL and GroES . . . . . . . . . . . . . . . . . . . . . . . . . . 447 The Clp Protease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 448 The DegP Protease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 452
2,255 citations
Cites background from "The heat-shock response"
...high concentrations of ethanol, arsenite, or heavy metals) (147, 188, 220, 250)....
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