Journal ArticleDOI
The heparin-binding (fibroblast) growth factor family of proteins.
Wilson H. Burgess,Thomas Maciag +1 more
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This article is published in Annual Review of Biochemistry.The article was published on 1989-01-01. It has received 1994 citations till now. The article focuses on the topics: Fibroblast growth factor binding & Heparin Binding Growth Factor.read more
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
Journal ArticleDOI
The fms-Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor
TL;DR: Findings show that flt encodes a receptor for VEGF-VPF, a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation.
Journal ArticleDOI
Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation.
TL;DR: Prevention of binding between cell surface heparan sulfate and bFGF substantially reduces binding of fibroblast growth factor to its cell-surface receptors, blocks the ability of bF GF to support the growth of Swiss 3T3 fibroblasts, and induces terminal differentiation of MM14 skeletal muscle cells, which is normally repressed by fibro Blast growth factor.
Journal ArticleDOI
Fibroblast growth factors, their receptors and signaling.
TL;DR: FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.
Journal ArticleDOI
Proteoglycans as modulators of growth factor activities
Erkki Ruoslahti,Yu Yamaguchi +1 more
TL;DR: Proteoglycans bind to extracellular proteins such as fibronectin and are found to be binders of many growth factors.
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The neurite-promoting effect of fibroblast growth factor on PC12 cells
TL;DR: Treatment of PC12 cells with fibroblast growth factor(s) from either brain or pituitary caused neurite outgrowth comparable to that produced by nerve growth factor.