The hippocampal-prefrontal pathway: The weak link in psychiatric disorders?
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TLDR
The H-PFC pathway is a potentially crucial element of the pathophysiology of several psychiatric diseases, and it offers a specific target for therapeutic intervention, which is consistent with the recent emphasis on reframing psychiatric diseases in terms of brain circuits.About:
This article is published in European Neuropsychopharmacology.The article was published on 2013-10-01 and is currently open access. It has received 350 citations till now. The article focuses on the topics: Prefrontal cortex & Emotional dysregulation.read more
Citations
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Journal ArticleDOI
Hippocampal GABAergic Inhibitory Interneurons.
Kenneth A. Pelkey,Ramesh Chittajallu,Michael T. Craig,Ludovic Tricoire,Ludovic Tricoire,Jason C. Wester,Jason C. Wester,Chris J. McBain,Chris J. McBain +8 more
TL;DR: An overview of the current state of the field of interneuron research, focusing largely on the hippocampus, discusses recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations.
Journal ArticleDOI
A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications.
Lívea Dornela Godoy,Matheus Teixeira Rossignoli,Polianna Delfino-Pereira,N. Garcia-Cairasco,Eduardo H.L. Umeoka +4 more
TL;DR: The identification of neuronal circuits of stress, as well as their interaction with mediator molecules over time is critical, not only for understanding the physiological stress responses, but also to understand their implications on mental health.
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Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine
Marc S. Lener,Mark J. Niciu,Elizabeth D. Ballard,Minkyung Park,Lawrence Park,Allison C. Nugent,Carlos A. Zarate +6 more
TL;DR: Future studies in depression will require a combination of neuroimaging approaches from which more biologically homogeneous subgroups can be identified, particularly with respect to treatment response biomarkers of glutamatergic modulation.
Journal ArticleDOI
Prefrontal-Hippocampal Interactions in Memory and Emotion.
Jingji Jin,Stephen Maren +1 more
TL;DR: Bidirectional interactions between the HPC and mPFC are involved in working memory, episodic memory and emotional memory in animals and humans and how dysfunction in bidirectional HPC-mPFC pathways contributes to psychiatric disorders is considered.
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Hippocampal-Prefrontal Interactions in Cognition, Behavior and Psychiatric Disease.
Torfi Sigurdsson,Sevil Duvarci +1 more
TL;DR: The goal of this review is to summarize what is known about the role of hippocampal-prefrontal interactions in normal brain function and compare how these interactions are disrupted in schizophrenia patients and animal models of the disease.
References
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The Brain's Default Network Anatomy, Function, and Relevance to Disease
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Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
TL;DR: As an adjunct to pharmaceutical therapy, social and behavioral interventions such as regular physical activity and social support reduce the chronic stress burden and benefit brain and body health and resilience.
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Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures
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