The immunology of asthma
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Cites background from "The immunology of asthma"
...Nevertheless, the type-2-cellmediated response can also be very detrimental; for example, the smooth muscle contraction and mucus production after inhalation of harmless allergens leads to chronic airway narrowing in asthma and can also cause acute death in anaphylaxis (Lambrecht and Hammad, 2015)....
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560 citations
Cites background from "The immunology of asthma"
...However, when allergens have additional protease activity and/or are accompanied by microbial components, such as endotoxins or inorganic particles, epithelial secretory responses can lead to mixed TH2 and TH17 immunity or even TH1 responses.(42,43) In response to viruses, epithelial cells produce a wide range of mediators, such as type I interferons, GM-CSF, RANTES/CCL5, and IFN-g–induced protein 1/CXCL10....
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References
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