Journal ArticleDOI
The influence of freeze-thawing conditions on swelling and long-term stability properties of poly(vinyl alcohol) hydrogels for controlled drug release
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In this article, the swelling capacity and long-term stability of polyvinyl alcohol (PVA) hydrogels were determined as a function of time at pH 2.1, 5.5 and 7.4 and displayed controlled release for 120 h.Abstract:
The preparation of poly(vinyl alcohol) (PVA) hydrogels was succeeded via the freeze-thawing (F/T) method by varying the synthesis parameter conditions. The swelling capacity and long-term stability of the hydrogels were determined as a function of time at pH 2.1, 5.5 and 7.4 and found to be mainly affected by the synthesis parameter conditions. These studies showed that the swelling ratio generally increased with a low number of F/T cycles (2 and 3), high freezing temperature (− 5 and − 16 °C) and freeze-dried of drying type for all three pH mediums. The dried hydrogels at room temperature were found to be more stable hydrogels. In addition, the drug release studies of salicylic acid as a drug model were investigated at pH 7.4 and displayed controlled release for 120 h. The release kinetic studies obtained from drug release data demonstrated that the PVA hydrogel fits well into the Higuchi model. The release mechanism of PVA hydrogel was also determined as super case II type.read more
Citations
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Current Understanding of Hydrogel for Drug Release and Tissue Engineering
TL;DR: The characteristics and crosslinking methods of natural and synthetic hydrogels are introduced and the design and principle of intelligent hydrogel used for drug release and tissue engineering are highlighted.
Journal ArticleDOI
Utilization of freeze thaw process for polyvinyl alcohol/sodium alginate (PVA/SA) hydrogel composite
TL;DR: In this article , a polyvinyl alcohol/sodium alginate (PVA/SA) hydrogel was successfully prepared by freeze thaw process without crosslinking agent.
Journal ArticleDOI
Construction of double-network hydrogel based on low methoxy pectin/polyvinyl alcohol and its structure and properties.
TL;DR: In this paper , an interpenetrating double-network hydrogel (LMP/AA/PVAH) was prepared based on low methoxy pectin, acrylic acid (AA) and polyvinyl alcohol (PVA).
Posted ContentDOI
Study of Hybrid Hydrogel Based on Polyvinyl Alcohol with Respect to Tailoring of the Internal Structure by Lecithin
TL;DR: In this paper , the authors focused on the preparation and subsequent characterization of structural and transport properties of hydrogels with double-network concerning their application potential, and they were prepared as a combination of synthetic polymer and natural polysaccharide, such as polyvinyl alcohol (PVA) and sodium alginate (SA), where mass ratio of those polymers was 1:1.
References
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TL;DR: The nonlinear K-profiles clustering method is designed, which can be seen as the nonlinear counterpart of the K-means clustering algorithm, and has a built-in statistical testing procedure that ensures genes not belonging to any cluster do not impact the estimation of cluster profiles.
Journal ArticleDOI
Structure and Morphology of Freeze/Thawed PVA Hydrogels
TL;DR: The structure and morphology of polyvinyl alcohol (PVA) gels prepared by repeated cycles of 8 h freezing at −20 °C and 4 h thawing at +25 °C were examined in this paper.
Journal ArticleDOI
Synthesis and biomedical applications of hollow nanostructures
Kwangjin An,Taeghwan Hyeon +1 more
TL;DR: In this article, a review article covers recent progress concerning the synthesis of hollow nanostructures with their sizes smaller than 200nm and their biomedical applications including specific targeting, imaging, and controlled release of therapeutics for simultaneous diagnosis and therapy.
Journal ArticleDOI
3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems.
Alvaro Goyanes,Usanee Det-Amornrat,Jie Wang,Abdul Basit,Abdul Basit,Simon Gaisford,Simon Gaisford +6 more
TL;DR: SLA printing was the more appropriate 3D printing technology to manufacture anti-acne devices with salicylic acid and 3D scanning technology was used to obtain a 3D model of a nose adapted to the morphology of an individual.
Journal ArticleDOI
Drug physical state and drug-polymer interaction on drug release from chitosan matrix films.
TL;DR: It was suggested that the swelling property, dissolution characteristics of the polymer films, pK(a) of drugs and especially drug-polymer interaction were important factors governing drug release patterns from chitosan films.