The interferon signature in autoimmune diseases.
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914 citations
Cites background from "The interferon signature in autoimm..."
...A major feature of mononuclear and tissue cells from SLE patients is a gene expression profile that makes them appear as if they were stimulated by type I interferons; this profile is referred to as the interferon signature (215)....
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References
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"The interferon signature in autoimm..." refers background in this paper
...The signature was found to correlate with disease activity and severity, the latter measured as nephritis and involvement of the CNS [3], and it could be modulated by glucocorticosteroid treatment [2]....
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...A role of type I IFN in diseases affecting central nervous system (CNS), such as neuropsychiatric SLE and Aicardi–Goutieres syndrome have also been suggested (rev. in [22])....
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...In the initial studies, it was noted that almost all children with SLE display an IFN signature [2], whereas only half of the adult SLE patients exhibited a clear IFN signature [3]....
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1,873 citations
"The interferon signature in autoimm..." refers background in this paper
...The signature was found to correlate with disease activity and severity, the latter measured as nephritis and involvement of the CNS [3], and it could be modulated by glucocorticosteroid treatment [2]....
[...]
...In the initial studies, it was noted that almost all children with SLE display an IFN signature [2], whereas only half of the adult SLE patients exhibited a clear IFN signature [3]....
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1,628 citations
"The interferon signature in autoimm..." refers background in this paper
...[13] found that the antimicrobial peptide LL37 binds and protects DNA or RNA from degradation, and allowed access of such complexes to early endosomes and triggering of TLR9 and TLR7....
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870 citations
590 citations
"The interferon signature in autoimm..." refers background in this paper
...The first identified SLE risk gene in the type I IFN pathway was IRF5 [15], which has an increased expression in SLE patients [16] and is activated in these individuals [17 & ]....
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...& Wang C, Sandling JK, Hagberg N, et al. Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4....
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...[Epub ahead of print] This is the first study of Chromatin Immunoprecipitation-sequencing of genes targeted by IRF5 and STAT4....
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...The SLE risk haplotype in IRF5 is associated with serum IFN-a activity [18] and recent studies [19 & ] have shown that IRF5 target thorized reproduction of this article is prohibited. ins www.co-rheumatology.com 249 C Immunopathogenesis and treatment of autoimmune diseases genes are enriched for type I IFN regulated genes and that the expression pattern of these are characteristics for SLE patients....
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...This is the first study that demonstrates an increased nuclear translocation of IRF5 in cells from SLE patients....
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