The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens.
Citations
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440 citations
Cites background from "The intestinal microbiota: Antibiot..."
...The Firmicutes and Bacteroidetes constitute 90%, and the Proteobacteria and Actinomycetes are consistent but less abundant constituents [16]....
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...Certainly, much of the microbiome can be repopulated by organisms protected in crypts within the epithelial mucous layer [16], and interactions between less abundant species may be important for maintenance of the overall structure of the individual microbiome [19]....
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255 citations
Cites background from "The intestinal microbiota: Antibiot..."
...Such an uncertainty, for instance, applies to the antibiotic metronidazole [137, 138], which not only is absorbed from the intestine and enters the brain, but may also exert neurotoxic effects [139, 140]....
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...Hence, it is important to choose antibiotics, that are not or only minimally absorbed from the gastrointestinal tract, and to validate this condition in the experimental animal species used [137]....
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247 citations
Cites background from "The intestinal microbiota: Antibiot..."
...Although mechanisms behind this resistance are not clear, it has been suggested that commensal bacterial species compete with pathogens for niche space and produce and secrete antimicrobial peptides (67)....
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...It has been proposed that the microbiota protects the host from colonization and proliferation of environmental pathogens, a process known as “colonization resistance” (67, 68)....
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223 citations
References
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