Journal ArticleDOI
The kinetics of the tissue distribution of silver nanoparticles of different sizes.
Danille P K Lankveld,AG Oomen,Petra Krystek,Arianne M. Neigh,A. Troost de Jong,Cornelle W. Noorlander,J. C H Van Eijkeren,Geertsma Re,W.H. de Jong +8 more
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TLDR
A physiologically based pharmacokinetic model for nanoparticles which describes the kinetics of silver nanoparticles was developed and resulted in accumulation in liver, lung and spleen, indicating that these organs may be potential target organs for toxicity after repeated exposure.About:
This article is published in Biomaterials.The article was published on 2010-11-01. It has received 459 citations till now. The article focuses on the topics: Silver nanoparticle.read more
Citations
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Journal ArticleDOI
Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal
TL;DR: It can be concluded that the therapeutic window for silver is narrower than often assumed, however, the risks for humans and the environment are probably limited.
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Mechanisms of Silver Nanoparticle Release, Transformation and Toxicity: A Critical Review of Current Knowledge and Recommendations for Future Studies and Applications.
TL;DR: A critical assessment of the current understanding of silver nanoparticle toxicity is provided and a set of pointers and guidelines for experimental design of future studies to assess the environmental and biological impacts of nanosilver are provided.
Journal ArticleDOI
The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles.
Margriet V. D. Z. Park,Margriet V. D. Z. Park,Arianne M. Neigh,Jolanda P. Vermeulen,Liset J.J. de la Fonteyne,Henny W. Verharen,Jacob J. Briedé,Henk Van Loveren,Henk Van Loveren,Wim H. de Jong +9 more
TL;DR: Effects of silver nanoparticles on different toxic endpoints may be the consequence of their ability to inflict cell damage, and the potency of silver in the form of nanoparticles to induce cell damage compared to silver ions is cell type and size-dependent.
Journal ArticleDOI
Intrinsic therapeutic applications of noble metal nanoparticles: past, present and future
Rochelle R. Arvizo,Sanjib Bhattacharyya,Rachel A. Kudgus,Karuna Giri,Resham Bhattacharya,Priyabrata Mukherjee +5 more
TL;DR: This critical review will discuss the various clinical applications of gold, silver and platinum nanoparticles with relevance to above parameters and mention various routes of synthesis of these noble metal nanoparticles.
Journal ArticleDOI
Distribution, Elimination, and Toxicity of Silver Nanoparticles and Silver Ions in Rats after 28-Day Oral Exposure
Meike van der Zande,Rob J. Vandebriel,Elke Van Doren,Evelien Kramer,Zahira E. Herrera Rivera,Cecilia S. Serrano-Rojero,Eric R. Gremmer,Jan Mast,Ruud J. B. Peters,Peter C. H. Hollman,Peter J.M. Hendriksen,Hans J.P. Marvin,Ad A. C. M. Peijnenburg,Hans Bouwmeester +13 more
TL;DR: Oral exposure toSilver nanoparticles appears to be very similar to exposure to silver salts, however, the consequences of in vivo formation of silver nanoparticles, and of the long retention of silver in brain and testis should be considered in a risk assessment ofsilver nanoparticles.
References
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Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Journal ArticleDOI
Silver nanoparticles as a new generation of antimicrobials.
TL;DR: Silver nanoparticles have emerged up with diverse medical applications ranging from silver based dressings, silver coated medicinal devices, such as nanogels, nanolotions, etc, due to its capability of modulating metals into their nanosize.
Journal ArticleDOI
Renal clearance of quantum dots.
Hak Soo Choi,Wenhao Liu,Preeti Misra,Eiichi Tanaka,John P. Zimmer,Binil Itty Ipe,Moungi G. Bawendi,John V. Frangioni,John V. Frangioni +8 more
TL;DR: This study has precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles and provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications.
Journal ArticleDOI
Nanosilver: a nanoproduct in medical application.
Xiao Chen,Hermann J. Schluesener +1 more
TL;DR: Use of nanosilver is becoming more and more widespread in medicine and related applications and due to increasing exposure toxicological and environmental issues need to be raised.
Journal ArticleDOI
Particle size-dependent organ distribution of gold nanoparticles after intravenous administration.
Wim H. de Jong,Werner I. Hagens,Petra Krystek,Marina C. Burger,Adriënne J.A.M. Sips,Geertsma Re +5 more
TL;DR: It is demonstrated that tissue distribution of gold nanoparticles is size-dependent with the smallest 10nm nanoparticles showing the most widespread organ distribution.