The Lambeth Conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias
St Thomas' Hospital1, University of Szeged2, Robert Gordon University3, University of Michigan4, University of Adelaide5, West Virginia School of Osteopathic Medicine6, Ohio State University7, University of Amsterdam8, Johnson & Johnson9, University of Leicester10, Vanderbilt University11, St George's, University of London12, University of British Columbia13
TL;DR: This work has updated the guidance on the design and execution of experiments and the definition, classification, quantification, and analysis of all types of arrhythmias, and urges investigators to adopt the conventions.
About: This article is published in Pharmacology & Therapeutics.The article was published on 2013-08-01. It has received 255 citations till now.
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TL;DR: In this article, the authors present a series of linked editorials in the context of biomedical journal abstracts, including: http://onlinelibrary.wiley.com/doi/10.1111/bph.12954/abstract, http://Onlinelabel. wiley. com/doi /10.12956/ABstract, https://www.wired.org/content/index.cfm/
Abstract: Linked Editorials
This Editorial is part of a series. To view the other Editorials in this series, visit: http://onlinelibrary.wiley.com/doi/10.1111/bph.12956/abstract; http://onlinelibrary.wiley.com/doi/10.1111/bph.12954/abstract; http://onlinelibrary.wiley.com/doi/10.1111/bph.12955/abstract and http://onlinelibrary.wiley.com/doi/10.1111/bph.13112/abstract
939 citations
University of Mississippi Medical Center1, Veterans Health Administration2, University of Louisville3, University at Buffalo4, The Heart Research Institute5, Albert Einstein College of Medicine6, University of Würzburg7, Virginia Tech8, University of Virginia9, Huntington Medical Research Institutes10, University of Southern California11, Louisiana State University12, Harvard University13, National Institutes of Health14, University of California, Los Angeles15, Wayne State University16, Temple University17, Sant'Anna School of Advanced Studies18, University of California, Davis19, Cedars-Sinai Medical Center20, University of Duisburg-Essen21
TL;DR: The goal of this review is to provide best practice information regarding myocardial ischemia-reperfusion and infarction models and to provide increasing awareness of the need for rigor and reproducibility in designing and performing scientific research to ensure validation of results.
Abstract: Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational research is needed to better understand...
357 citations
Cites background from "The Lambeth Conventions (II): Guide..."
...Updated guidelines exist for the quantification of such arrhythmias (56)....
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TL;DR: A systematic review of preclinical research guidelines and organized recommendations according to the type of validity threat (internal, construct, or external) or programmatic research activity they primarily address provided a starting point for developing preclinical guidelines in other disease domains.
Abstract: Background
The vast majority of medical interventions introduced into clinical development prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed preclinical research. We conducted a systematic review of preclinical research guidelines and organized recommendations according to the type of validity threat (internal, construct, or external) or programmatic research activity they primarily address.
258 citations
Journal Article•
TL;DR: The present study investigates the cellular basis for the J wave using an isolated arterially perfused preparation consisting of a wedge of canine right or left ventricle, and observed a J wave at the R-ST junction of the ECG in 17 of 20 adult dogs.
Abstract: Background The J wave is a deflection that appears in the ECG as a late delta wave following the QRS or as a small secondary R wave (R′). Also referred to as an Osborn wave, the J wave has been observed in the ECG of animals and humans for more than four decades, yet the mechanism underlying its manifestation is poorly understood. The present study investigates the cellular basis for the J wave using an isolated arterially perfused preparation consisting of a wedge of canine right or left ventricle. Methods and Results A 12-lead ECG was initially recorded in vivo. After isolation and arterial perfusion of the right or left ventricular wedge, transmembrane action potentials were simultaneously recorded from epicardial, M region, and endocardial transmural sites with three floating microelectrodes. A transmural ECG was recorded concurrently. A J wave was observed at the R-ST junction of the ECG in 17 of 20 adult dogs, usually in leads II, III, aVR, and aVF and the mid to lateral precordial leads. The J wave...
183 citations
TL;DR: The physiological mechanisms underlying differences between the baseline ECG of humans and mice are discussed, and a framework for understanding how these inherent differences are relevant to the interpretation of the mouse ECG during pathology and to the translation of the results from the mouse to man is provided.
Abstract: The ECG is a primary diagnostic tool in patients suffering from heart disease, underscoring the importance of understanding factors contributing to normal and abnormal electrical patterns Over the past few decades, transgenic mouse models have been increasingly used to study pathophysiological mechanisms of human heart diseases In order to allow extrapolation of insights gained from murine models to the human condition, knowledge of the similarities and differences between the mouse and human ECG is of crucial importance In this review, we briefly discuss the physiological mechanisms underlying differences between the baseline ECG of humans and mice, and provide a framework for understanding how these inherent differences are relevant to the interpretation of the mouse ECG during pathology and to the translation of the results from the mouse to man
102 citations
Cites background from "The Lambeth Conventions (II): Guide..."
...In mice, however, reentry can only be induced in a small fraction of healthy hearts via this method, and episodes of ventricular fibrillation usually have a short duration and terminate spontaneously (Walker et al. 1988; Curtis et al. 2013)....
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...However, in healthy large animals (including pig and dog), as well as humans, reentry can always be induced by burst pacing with multiple ventricular premature stimuli (Wellens et al. 1985; Walker et al. 1988; Curtis et al. 2013)....
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References
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Book•
01 Jan 1962TL;DR: In this article, the authors introduce the principles of estimation and inference: means and variance, means and variations, and means and variance of estimators and inferors, and the analysis of factorial experiments having repeated measures on the same element.
Abstract: CHAPTER 1: Introduction to Design CHAPTER 2: Principles of Estimation and Inference: Means and Variance CHAPTER 3: Design and Analysis of Single-Factor Experiments: Completely Randomized Design CHAPTER 4: Single-Factor Experiments Having Repeated Measures on the Same Element CHAPTER 5: Design and Analysis of Factorial Experiments: Completely-Randomized Design CHAPTER 6: Factorial Experiments: Computational Procedures and Numerical Example CHAPTER 7: Multifactor Experiments Having Repeated Measures on the Same Element CHAPTER 8: Factorial Experiments in which Some of the Interactions are Confounded CHAPTER 9: Latin Squares and Related Designs CHAPTER 10: Analysis of Covariance
25,607 citations
TL;DR: This chapter discusses design and analysis of single-Factor Experiments: Completely Randomized Design and Factorial Experiments in which Some of the Interactions are Confounded.
24,665 citations
Additional excerpts
...Specific statistical tests are not discussed here; the reader should refer to reviews of statistical methodology (Mainland et al., 1956; Winer, 1962; Wallenstein et al., 1980)....
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16,221 citations