The let-7 microrna reduces tumor growth in mouse models of lung cancer
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..., are differentially expressed in different tissues and are involved in different human tumour...
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...Supporting this notion, two recent reports demonstrated that viral delivery of let-7 miRNAs suppressed tumor growth in a mouse model of lung adenocarcinoma (Esquela-Kerscher et al., 2008; Kumar et al., 2008)....
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...Using a conditional mouse lung cancer model, where conditional expression of oncogenic K-ras could be activated, EsquelaKerscher et al showed that the intranasal administration of an adenovirus expressing let-7a RNA hairpin reduced tumour formation in vivo (Esquela-Kerscher et al, 2008)....
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