The long lives of primates and the 'invariant rate of ageing' hypothesis.
Fernando Colchero,José Manuel Aburto,José Manuel Aburto,José Manuel Aburto,Elizabeth A. Archie,Christophe Boesch,Thomas Breuer,Thomas Breuer,Fernando A. Campos,Anthony Collins,Dalia Amor Conde,Marina Cords,Catherine Crockford,Melissa Emery Thompson,Linda M. Fedigan,Claudia Fichtel,Milou Groenenberg,Milou Groenenberg,Catherine Hobaiter,Peter M. Kappeler,Peter M. Kappeler,Richard R. Lawler,Rebecca J. Lewis,Zarin P. Machanda,Marie L. Manguette,Marie L. Manguette,Martin N. Muller,Craig Packer,Richard J. Parnell,Susan Perry,Anne E. Pusey,Martha M. Robbins,Robert M. Seyfarth,Joan B. Silk,Johanna Staerk,Tara S. Stoinski,Emma J. Stokes,Karen B. Strier,Shirley C. Strum,Jenny Tung,Francisco Villavicencio,Roman M. Wittig,Richard W. Wrangham,Klaus Zuberbühler,Klaus Zuberbühler,James W. Vaupel,James W. Vaupel,Susan C. Alberts +47 more
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The invariant rate of ageing hypothesis as mentioned in this paper suggests that the rate of aging is relatively fixed within species, with a collection of 39 human and nonhuman primate datasets across seven genera.Abstract:
Is it possible to slow the rate of ageing, or do biological constraints limit its plasticity? We test the 'invariant rate of ageing' hypothesis, which posits that the rate of ageing is relatively fixed within species, with a collection of 39 human and nonhuman primate datasets across seven genera. We first recapitulate, in nonhuman primates, the highly regular relationship between life expectancy and lifespan equality seen in humans. We next demonstrate that variation in the rate of ageing within genera is orders of magnitude smaller than variation in pre-adult and age-independent mortality. Finally, we demonstrate that changes in the rate of ageing, but not other mortality parameters, produce striking, species-atypical changes in mortality patterns. Our results support the invariant rate of ageing hypothesis, implying biological constraints on how much the human rate of ageing can be slowed.read more
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Social ageing: exploring the drivers of late-life changes in social behaviour in mammals
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References
More filters
Book
Bayesian Data Analysis
TL;DR: Detailed notes on Bayesian Computation Basics of Markov Chain Simulation, Regression Models, and Asymptotic Theorems are provided.
Journal ArticleDOI
Broken Limits to Life Expectancy
Jim Oeppen,James W. Vaupel +1 more
TL;DR: The evidence presented in this paper suggests that the apparent leveling off of life expectancy in various countries is an artifact of laggards catching up and leaders falling behind, not a sign that life expectancy is approaching its limit.
Journal ArticleDOI
Avian life history variation and contribution of demographic traits to the population growth rate
Bernt-Erik Sæther,Øyvind Bakke +1 more
TL;DR: Based on the asymptotic population growth rate l, calculated from a projection matrix model as a descriptor of the population dynamics, published data of 49 species of birds are analyzed to determine how l is influenced by variation in different demographic traits.
Journal ArticleDOI
Biodemography of human ageing.
TL;DR: Research by demographers, epidemiologists and other biomedical researchers suggests that further progress is likely to be made in advancing the frontier of survival — and healthy survival — to even greater ages.
Book
Applied Mathematical Demography
TL;DR: In this paper, the authors proposed a matrix model framework for estimating fertility and mortality in a population without age, which is based on the Markov chain for individual life history and fertility.