The lysosome: from waste bag to potential therapeutic target
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Cites background from "The lysosome: from waste bag to pot..."
...We have recently performed a systematic look at the proteomic effects of defective endosomal-lysosomal pH in a cellular model, in order to develop a better understanding of the global changes in the proteome that follow inhibition of V-ATPase and could be considered together as a signature or biomarker of defective vacuolar acidification [57, 58], which would be expected to have an overlap with changes seen in AD and/or other conditions which may be subject to this often agedependent defect....
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References
6,301 citations
"The lysosome: from waste bag to pot..." refers background in this paper
...Due to the essential role of lysosomes in autophagy, lysosomal dysfunction impairs this process, thereby contributing to disease (Levine and Kroemer, 2008)....
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...Due to the essential role of lysosomes in autophagy, lysosomal dysfunction impairs this process, thereby contributing to disease (Levine and Kroemer, 2008)....
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5,488 citations
"The lysosome: from waste bag to pot..." refers background in this paper
...In addition to de novo cholesterol synthesis in the ER, the uptake of low-density lipoprotein (LDL) via receptor-mediated endocytosis is an important route for cholesterol entry into the cell (Brown and Goldstein, 1986)....
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4,529 citations
"The lysosome: from waste bag to pot..." refers background in this paper
...There is normally a basal rate of autophagy in cells to maintain homeostasis, but it can be strongly induced to protect cells under various physiological stresses, such as nutrient depletion and the presence of aggregated proteins (Mizushima and Komatsu, 2011)....
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...This secures the supply of building blocks in the cell during starvation and permits the disposal of unneeded or non-functional organelles (Mizushima and Komatsu, 2011)....
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4,177 citations
"The lysosome: from waste bag to pot..." refers background in this paper
...Such extracellular ATP participates in communication that is mediated by a range of different ATP binding receptors (Ralevic and Burnstock, 1998)....
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3,684 citations
"The lysosome: from waste bag to pot..." refers background in this paper
...Correct autophagic function is essential for cells, particularly for neurons, which rely on autophagy for survival, and the inactivation of crucial autophagy genes in mice results in severe neurodegeneration (Hara et al., 2006; Komatsu et al., 2006)....
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