The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.
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Cites background from "The mechanism of alloxan and strept..."
...After decades of research a unifying explanation for the selective toxicity of these two most prominent diabetogenic agents [2, 17–22] can be provided....
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1,023 citations
Cites background from "The mechanism of alloxan and strept..."
...Alloxan is reduced to dialuric acid and then re-oxidized back to alloxan, creating a redox cycle for the generation of superoxide radicals that undergo dismutation to form hydrogen peroxide and thereafter highly reactive hydroxyl radicals that cause fragmentation of beta cell DNA (Szkudelski, 2001)....
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...Doses in mice range from 50 to 200 mg·kg-1 and in rats from 40 to200 mg·kg-1, depending on the strain and the route of administration with i.p and s.c. administration requiring up to three times as high a dose as the i.v. route (Szkudelski, 2001)....
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...It should be noted that alloxan has a narrow diabetogenic dose, and even light overdosing can cause general toxicity, especially to the kidney (Szkudelski, 2001)....
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...administration, it enters the pancreatic beta cell through the Glut-2 transporter and causes alkylation of the DNA (Szkudelski, 2001)....
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...After i.p. or i.v. administration, it enters the pancreatic beta cell through the Glut-2 transporter and causes alkylation of the DNA (Szkudelski, 2001)....
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"The mechanism of alloxan and strept..." refers background in this paper
...However, the liver and other tissues are more resistant to reactive oxygen species in comparison to pancreatic B cells and this resistance protects them against alloxan toxicity (Malaisse et al. 1982, Tiedge et al. 1997)....
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"The mechanism of alloxan and strept..." refers background in this paper
...Recent experiments have proved that the main reason for the STZ-induced B cell death is alkylation of DNA (Delaney et al. 1995, Elsner et al. 2000)....
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292 citations