The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction
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...Lastly, the characterization of Csf1r and Flt3 as direct Pax5 target genes indicated that Pax5 is able to mediate gene repression by binding to proximal promoter region...
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...1D) (Tagoh et al. 2006; Bonifer and Hume 2008)....
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...Pax5 also represses the MCSFR promoter through direct interaction (Tagoh et al., 2006)....
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"The mechanism of repression of the ..." refers background in this paper
...…Biology Organization The EMBO Journal VOL 25 | NO 5 | 2006 1073 Repression of gene expression often involves the acquisition of inactive histone marks and the loss of active histone marks such as histone H3 lysine 4 methylation or lysine 9 acetylation, respectively (Jenuwein and Allis, 2001)....
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"The mechanism of repression of the ..." refers background in this paper
...PU.1 is an essential factor regulating c-fms expression, and elimination of this factor abolishes c-fms expression and blocks macrophage differentiation (Scott et al, 1994; Simon et al, 1996)....
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"The mechanism of repression of the ..." refers background in this paper
...…here, the consequence of this abrogation of activated transcription is a rapid loss of RNA-polymerase II binding, confirming published data demonstrating that the frequency of initiating a new transcription cycle is crucially dependent on the binding of upstream activators (Metivier et al, 2003)....
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"The mechanism of repression of the ..." refers background in this paper
...Expression of this growth factor receptor is crucial for macrophage differentiation and is developmentally regulated (Dai et al, 2002; Tagoh et al, 2002). c-fms is a target of the transcription factor PU.1 and is already expressed at a low level in HSCs....
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