Journal ArticleDOI
The mechanisms underlying olfactory deficits in apolipoprotein E-deficient mice: focus on olfactory epithelium and olfactory bulb.
Jiajia Zhang,Caiyuan Hao,Jinxiang Jiang,Yangjian Feng,Xi Chen,Ying Zheng,Jiawei Liu,Zhilin Zhang,Cheng Long,Li Yang +9 more
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TLDR
This study demonstrates the critical involvement of ApoE in olfactory information processing in the OE and OB and shows that gamma oscillation power was enhanced, which might be attributed to an increase in GABAergic inhibition mediated by parvalbumin-expressing interneurons.About:
This article is published in Neurobiology of Aging.The article was published on 2018-02-01. It has received 22 citations till now. The article focuses on the topics: Olfaction & Olfactory bulb.read more
Citations
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Journal ArticleDOI
The human olfactory system in two proteinopathies: Alzheimer’s and Parkinson’s diseases
Isabel Ubeda-Bañon,Daniel Saiz-Sanchez,Alicia Flores-Cuadrado,Ernesto Rioja-Corroto,Melania Gonzalez-Rodriguez,Sandra Villar-Conde,Veronica Astillero-Lopez,Juan Pablo Cabello-de la Rosa,Maria Jose Gallardo-Alcañiz,Julia Vaamonde-Gamo,Fernanda Relea-Calatayud,Lucia Gonzalez-Lopez,Alicia Mohedano-Moriano,Alberto Rábano,Alino Martinez-Marcos +14 more
TL;DR: Connectomic approaches reveal a number of hubs in the olfactory system that are key interconnectors with the main hubs of network dysfunction in Alzheimer's and Parkinson's diseases, and why some neuronal populations are vulnerable while others are resistant to pathology and to what extent glia prevent and/or facilitate proteinopathy spreading.
Journal ArticleDOI
Functional Connectivity between the Resting-State Olfactory Network and the Hippocampus in Alzheimer's Disease.
Jiaming Lu,Jiaming Lu,Nicole Testa,Rebecca Jordan,Rommy Elyan,Sangam Kanekar,Jianli Wang,Paul J. Eslinger,Qing X. Yang,Bing Zhang,Prasanna Karunanayaka +10 more
TL;DR: Findings provide the first in vivo evidence for the involvement of FC between the ON and hippocampus in AD pathology, and suggest that functional connectivity between the olfactory network (ON) and hippocampus may be a sensitive marker for Alzheimer’s disease (AD) progression, preceding gray matter volume loss.
Journal ArticleDOI
Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models
Ming Chen,Ming Chen,Yunan Chen,Qingwei Huo,Lei Wang,Shuyi Tan,Afzal Misrani,Jinxiang Jiang,Jian Chen,Shiyuan Chen,Jia-wei Zhang,Sidra Tabassum,Jichen Wang,Xi Chen,Cheng Long,Li Yang +15 more
TL;DR: In this article, the authors conducted in vivo measurement of local field potential (LFP) with a combination of electroolfactogram (EOG), whole-cell patch and field recordings to evaluate oscillatory and synaptic function and pharmacological regulation in the olfactory pathway.
Journal ArticleDOI
Alzheimer's Disease: What Can We Learn From the Peripheral Olfactory System?
TL;DR: Olfactory impairments could be used to understand the molecular mechanisms involved in the early phases of the pathology, highlighting how the olfactory epithelium and the OB are particularly sensitive to changes in proteins and enzymes involved in AD pathogenesis.
Journal ArticleDOI
Microglial activation in the dorsal striatum participates in anxiety-like behavior in Cyld knockout mice.
TL;DR: Results suggest that Cyld knockout leading to microglial activation promotes IL-1 β and TNF- α expression and acts as a critical pathway in the pathophysiology of anxiety.
References
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Journal ArticleDOI
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
TL;DR: Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, through its interaction with these receptors, participates in the transport of cholesterol and other lipids among various cells of the body.
Journal ArticleDOI
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
TL;DR: The A β-dependent and Aβ-independent mechanisms that link Apo-E4 status with AD risk are discussed, and how to design effective strategies for AD therapy by targeting ApO-E is considered.
Journal ArticleDOI
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
TL;DR: Optogenetics opens the door to a new kind of informational analysis of brain function, permitting quantitative delineation of the functional significance of individual elements in the emergent operation and function of intact neural circuitry.
Journal ArticleDOI
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
TL;DR: Apolipoprotein E-deficient mice generated by gene targeting were used to test this hypothesis and to make a mouse model for spontaneous atherosclerosis, with severe yet viable phenotype that should make them valuable for investigating genetic and environmental factors that modify the atherogenic process.
Journal ArticleDOI
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.
Paige E. Cramer,John R. Cirrito,Daniel W. Wesson,Daniel W. Wesson,C. Y. Daniel Lee,J. Colleen Karlo,Adriana E. Zinn,Brad T. Casali,Jessica L. Restivo,Whitney D. Goebel,Michael J. James,Kurt R. Brunden,Donald A. Wilson,Gary E. Landreth +13 more
TL;DR: Oral administration of the RXR agonist bexarotene to a mouse model of AD resulted in enhanced clearance of soluble Aβ within hours in an apoE-dependent manner, and stimulated the rapid reversal of cognitive, social, and olfactory deficits and improved neural circuit function.
Related Papers (5)
Anxiety- and Depression-Like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice.
Eleni Siopi,Eleni Siopi,Marie Denizet,Marie Denizet,Marie-Madeleine Gabellec,Marie-Madeleine Gabellec,Fabrice de Chaumont,Fabrice de Chaumont,Jean-Christophe Olivo-Marin,Jean-Christophe Olivo-Marin,Jean-Philippe Guilloux,Pierre-Marie Lledo,Pierre-Marie Lledo,Françoise Lazarini,Françoise Lazarini +14 more