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Journal ArticleDOI

The merits of the ICD for inherited heart rhythm disorders: A critical re-appraisal.

01 Oct 2020-Trends in Cardiovascular Medicine (Trends Cardiovasc Med)-Vol. 30, Iss: 7, pp 415-421
TL;DR: The evidence of ICD benefit and harm in IHRD is summarized, current knowledge gaps are highlighted, and alternative and adjunctive options to the transvenous ICD are proposed.
About: This article is published in Trends in Cardiovascular Medicine.The article was published on 2020-10-01. It has received 2 citations till now. The article focuses on the topics: Implantable cardioverter-defibrillator.
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Journal ArticleDOI
TL;DR: The evidence of ICD benefit and harm in IHRD is summarized, current knowledge gaps are highlighted, and alternative and adjunctive options to the transvenous ICD are proposed.
References
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Journal ArticleDOI
TL;DR: Common clinical and ECG features define a distinct syndrome in this group of patients with recurrent episodes of aborted sudden death unexplainable by currently known diseases, not explainable by electrolyte disturbances, ischemia or structural heart disease.

3,075 citations

Journal ArticleDOI
TL;DR: In this article, the authors proposed AMIOdarone versus implantable cardioverter-defibrillator (ICD-DV) for the treatment of atrial fibrillation.
Abstract: ACC : American College of Cardiology ACE : angiotensin-converting enzyme ACS : acute coronary syndrome AF : atrial fibrillation AGNES : Arrhythmia Genetics in the Netherlands AHA : American Heart Association AMIOVIRT : AMIOdarone Versus Implantable cardioverter-defibrillator:

2,830 citations

Journal ArticleDOI
TL;DR: This poster presents a probabilistic procedure to determine the best method for selecting a single drug to treat atrial fibrillation-like symptoms in patients with a history of atrialfibrillation.
Abstract: 2015 ESC Guidelines for the Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death

2,109 citations

Journal ArticleDOI
TL;DR: The cumulative probability of a first cardiac event, defined as the occurrence of syncope, cardiac arrest, or sudden death before the age of 40 years and before the initiation of therapy, was determined according to genotype, sex, and the QT interval corrected for heart rate.
Abstract: Background Mutations in potassium-channel genes KCNQ1 (LQT1 locus) and KCNH2 (LQT2 locus) and the sodium-channel gene SCN5A (LQT3 locus) are the most common causes of the long-QT syndrome. We stratified risk according to the genotype, in conjunction with other clinical variables such as sex and the length of the QT interval. Methods We evaluated 647 patients (386 with a mutation at the LQT1 locus, 206 with a mutation at the LQT2 locus, and 55 with a mutation at the LQT3 locus) from 193 consecutively genotyped families with the long-QT syndrome. The cumulative probability of a first cardiac event, defined as the occurrence of syncope, cardiac arrest, or sudden death before the age of 40 years and before the initiation of therapy, was determined according to genotype, sex, and the QT interval corrected for heart rate (QTc). Within each genotype we also assessed risk in the four categories derived from the combination of sex and QTc (<500 msec or ≥500 msec). Results The incidence of a first cardiac event bef...

1,283 citations