Journal ArticleDOI
The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine.
L Praveen Kumar,Sangeetha Kandoi,Ranjita Misra,S. Vijayalakshmi,Kalyanaraman Rajagopal,Rama Shanker Verma +5 more
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TLDR
This review will focus on the accumulating evidence that points to the therapeutic potential of the conditioned medium, both from pre-clinical and clinical studies, and the importance of profiling the conditionedmedium for assessing its potential for cell-free therapy therapy.About:
This article is published in Cytokine & Growth Factor Reviews.The article was published on 2019-04-01. It has received 224 citations till now. The article focuses on the topics: Mesenchymal stem cell & Regenerative medicine.read more
Citations
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Controversial Issue: Is it safe to employ mesenchymal stem cells in cell-based therapies?
TL;DR: An update regarding cellular senescence of MSC and recent insights concerning potential risks associated with their clinical use are presented.
Journal ArticleDOI
Adult mesenchymal stem cells and their exosomes: Sources, characteristics, and application in regenerative medicine.
TL;DR: The characteristics of human MSCs and their exosomes are highlighted, but also their latest therapeutic strategies in regenerative medicine are provided.
Journal ArticleDOI
Therapeutic applications of adipose cell-free derivatives: a review
TL;DR: Adipose cell-free derivatives have a broad therapeutic potential in many areas, as they possess anti-skin aging properties, promote wound healing, reduce scar formation, and provide myocardial protection and neuroprotection.
Journal ArticleDOI
Emergence of the Stem Cell Secretome in Regenerative Engineering.
Leila Daneshmandi,Shiv Shah,Tahereh Jafari,Maumita Bhattacharjee,Deandra Momah,Nikoo Saveh-Shemshaki,Kevin W.-H. Lo,Cato T. Laurencin +7 more
TL;DR: A step-by-step engineering approach is taken to evaluate the role of the stem cell secretome in regenerative engineering and the functional benefits and delivery systems and strategies that have been developed to use the secretome for tissue regeneration.
Journal ArticleDOI
Secretome of Adipose Tissue-Derived Stem Cells (ASCs) as a Novel Trend in Chronic Non-Healing Wounds: An Overview of Experimental In Vitro and In Vivo Studies and Methodological Variables.
Francesca Lombardi,Paola Palumbo,Francesca Rosaria Augello,Maria Grazia Cifone,Benedetta Cinque,Maurizio Giuliani +5 more
TL;DR: Results of in vitro and in vivo experimental studies on the pro-wound healing effects of ASC-secretome and/or extracellular vesicles (EVs) fully support the use of cell-free therapies for the treatment of chronic non-healing wounds.
References
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Journal ArticleDOI
The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells.
TL;DR: The linear increase in the number of colonies with increasing numbers of explanted cells and the distribution of male and female cells in mixed cultures support the view that fibroblast colonies are clones.
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Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
Edwin M. Horwitz,K. Le Blanc,Massimo Dominici,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Robert J. Deans,Diane S. Krause,Armand Keating +8 more
TL;DR: The mesenchymal stromal cells (MSC) as mentioned in this paper have been proposed as a more scientifically correct nomenclature for the fibroblast-like cells, regardless of the tissue from which they are isolated.
POSITION PAPER Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
Edwin M. Horwitz,K Le Blanc,Massimo Dominici,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Robert J. Deans,Diane S. Krause,Armand Keating +8 more
TL;DR: It is suggested that the fibroblast-like plastic-adherent cells, regardless of the tissue from which they are isolated, be termed multipotent mesenchymal stromal cells, while the term mesenchyal stem cells is used only for cells that meet specified stem cell criteria.
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Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone
Edwin M. Horwitz,Patricia L. Gordon,Winston K. K. Koo,Jeffrey C. Marx,Michael D. Neel,Rene Y. McNall,Linda M. Muul,Ted J. Hofmann +7 more
TL;DR: Allogeneic mesenchymal cells offer feasible posttransplantation therapy for osteogenesis imperfecta and likely other disorders originating in mesenchyal precursors, including bone, cartilage, and muscle.
Journal ArticleDOI
Clinical Trials with Mesenchymal Stem Cells: An Update:
TL;DR: Clinical trials using MSCs for representative diseases, including hematological disease, graft-versus-host disease, organ transplantation, diabetes, inflammatory diseases, and diseases in the liver, kidney, and lung are analyzed, as well as cardiovascular, bone and cartilage, neurological, and autoimmune diseases.