The microbiome and cancer
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TLDR
In this paper, the authors discuss links between the bacterial microbiota and cancer, with a particular focus on immune responses, dysbiosis, genotoxicity, metabolism and strategies to target the microbiome for cancer prevention.Abstract:
Microbiota and host form a complex 'super-organism' in which symbiotic relationships confer benefits to the host in many key aspects of life. However, defects in the regulatory circuits of the host that control bacterial sensing and homeostasis, or alterations of the microbiome, through environmental changes (infection, diet or lifestyle), may disturb this symbiotic relationship and promote disease. Increasing evidence indicates a key role for the bacterial microbiota in carcinogenesis. In this Opinion article, we discuss links between the bacterial microbiota and cancer, with a particular focus on immune responses, dysbiosis, genotoxicity, metabolism and strategies to target the microbiome for cancer prevention.read more
Citations
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The gut microbiota, bacterial metabolites and colorectal cancer
TL;DR: The relationship between diet, microbial metabolism and CRC is discussed and it is argued that the cumulative effects of microbial metabolites should be considered in order to better predict and prevent cancer progression.
Journal ArticleDOI
NF-κB, inflammation, immunity and cancer: coming of age
Koji Taniguchi,Michael Karin +1 more
TL;DR: How the initial discovery of a role for NF-κB in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity is discussed.
Journal ArticleDOI
New insights into cancer immunoediting and its three component phases — elimination, equilibrium and escape
TL;DR: This review focuses on important recent developments that have enhanced the understanding of each phase of the cancer immunoediting process, summarizes the discovery of new predictive and prognostic biomarkers and discusses development of novel and objectively effective cancer immunotherapies.
Journal ArticleDOI
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy.
Ta Chung Yu,Fangfang Guo,Ya-Nan Yu,Tian-Tian Sun,Dan Ma,Ji-Xuan Han,Yun Qian,Ilona Kryczek,Danfeng Sun,Nisha Nagarsheth,Ying-Xuan Chen,Haoyan Chen,Jie Hong,Weiping Zou,Jing-Yuan Fang +14 more
TL;DR: It is found that Fusobacterium (F.) nucleatum was abundant in colorectal cancer tissues in patients with recurrence post chemotherapy, and was associated with patient clinicopathological characterisitcs, and bioinformatic and functional studies demonstrated that F. nucleatum promoted coloreCTal cancer resistance to chemotherapy.
Journal ArticleDOI
Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis.
TL;DR: The mechanistic links between bile acids and gastrointestinal carcinogenesis in CRC and HCC are discussed, which involve two major bile acid-sensing receptors, farnesoid X receptor (FXR) and G protein-coupled bile Acid receptor 1 (TGR5).
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