The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1
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Cites background from "The mitochondria-targeted antioxida..."
...The mitochondrial quantity is maintained via mitochondrial dynamics and/or the selective clearance of damaged organelles [49]....
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Cites background or methods from "The mitochondria-targeted antioxida..."
...The mice were sacrificed at 24 weeks of age, and the kidneys were harvested as discussed previously [22]....
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...Moreover, previous studies by our laboratory and others have shown that mitochondrial ROS production plays a key role in the development of DN [22,26,41]....
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...HK-2 cells were pre-transfected with TXNIP or TRX siRNA using Lipofectamine 2000 (Life Technologies, USA), as previously described [22]....
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...MitoQ protects against a range of oxidation-related diseases, including cardiovascular disease [19], metabolic syndrome [20], Alzheimer's disease [21] and DN [22]....
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...Kidney tissue sections from humans or mice were prepared for IHC, as described in ref [22]....
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211 citations
Cites background from "The mitochondria-targeted antioxida..."
...In liver ischaemia-reperfusion injury, Sirt3 is unfortunately downregulated, whereas exogenous administration of Sirt3 attenuates reperfusion-mediated liver damage via maintaining mitochondrial calcium homeostasis and energetic balance [22,23]....
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References
780 citations
"The mitochondria-targeted antioxida..." refers methods in this paper
...[27] Nrf2-antioxidant response element (ARE) binding was measured using a TransAM Nrf2 Kit (active motif), as previously described....
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347 citations
"The mitochondria-targeted antioxida..." refers methods in this paper
...[3,26] Briefly, we fixed dissected renal cortices with 2....
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"The mitochondria-targeted antioxida..." refers background in this paper
...[19] Emerging data indicate that mitoQ may exert beneficial effects on tubular injury under various conditions....
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