The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain
Linda M. Wakim,Amanda Woodward-Davis,Ruijie Liu,Yifang Hu,Jose A Villadangos,Gordon K. Smyth,Gordon K. Smyth,Michael J. Bevan +7 more
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TLDR
Comparing the gene expression profiles of Trm cells isolated from the brain with those of circulating memory T cellsisolated from the spleen after an acute virus infection indicates that Trm Cells are a distinct memory T cell population disconnected from the circulatingMemory T cell pool and display a unique molecular signature that likely results in optimal survival and function within their local environment.Abstract:
Tissue resident memory (Trm) CD8 T cells represent a newly described memory T cell population. We have previously characterized a population of Trm cells that persists within the brain after acute virus infection. Although capable of providing marked protection against a subsequent local challenge, brain Trm cells do not undergo recall expansion after dissociation from the tissue. Furthermore, these Trm cells do not depend on the same survival factors as the circulating memory T cell pool as assessed either in vivo or in vitro. To gain greater insight into this population of cells, we compared the gene expression profiles of Trm cells isolated from the brain with those of circulating memory T cells isolated from the spleen after an acute virus infection. Trm cells displayed altered expression of genes involved in chemotaxis, expressed a distinct set of transcription factors, and overexpressed several inhibitory receptors. Cumulatively, these data indicate that Trm cells are a distinct memory T cell population disconnected from the circulating memory T cell pool and display a unique molecular signature that likely results in optimal survival and function within their local environment.read more
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The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin.
Laura K. Mackay,Azad Rahimpour,Joel Z. Ma,Nicholas Collins,Angus T. Stock,Ming-Li Hafon,Javier Vega-Ramos,Pilar Lauzurica,Scott N. Mueller,Tijana Stefanovic,David C. Tscharke,William R. Heath,Michael Inouye,Francis R. Carbone,Thomas Gebhardt +14 more
TL;DR: It is found that CD103+CD8+ TRM cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1.
Journal ArticleDOI
Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells
Anja Fuchs,William Vermi,William Vermi,Jacob S. Lee,Silvia Lonardi,Susan Gilfillan,Rodney D. Newberry,Marina Cella,Marco Colonna +8 more
TL;DR: A human ILC1 subset that produced interferon-γ (IFN-γ) in response to IL-12 and IL-15 and had a unique integrin profile, intraepithelial location, hallmarks of TGF-β imprinting, and a memory-activated phenotype is characterized.
Journal ArticleDOI
Tissue-Resident Memory T Cells
Jason M. Schenkel,David Masopust +1 more
TL;DR: This review will summarize current knowledge of Trm cell ontogeny, regulation, maintenance, and function and will highlight technical considerations for studying this population.
Journal ArticleDOI
Tissue-resident memory T cells: local specialists in immune defence
TL;DR: This Review discusses the major advances and the emerging concepts in this field, summarizes what is known about the differentiation and the protective functions of tissue-resident memory T cells in different tissues in the body and highlights key unanswered questions.
Journal ArticleDOI
Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites
Brahma V. Kumar,Wenji Ma,Michelle Miron,Tomer Granot,Rebecca S. Guyer,Dustin J. Carpenter,Takashi Senda,Xiaoyun Sun,Siu-hong Ho,Harvey Lerner,Amy L. Friedman,Yufeng Shen,Donna L. Farber +12 more
TL;DR: A core transcriptional profile within the CD69+ subset of memory CD4+ and CD8+ T cells in lung and spleen that is distinct from that of CD69- TEM cells in tissues and circulation is identified, providing a unifying signature for human TRM and a blueprint for designing tissue-targeted immunotherapies.
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