The MSC: An Injury Drugstore

doi:10.1016/J.STEM.2011.06.008

Open AccessJournal ArticleDOI

The MSC: An Injury Drugstore

Arnold I. Caplan, +1 more

- 08 Jul 2011 -

Cell Stem Cell

- Vol. 9, Iss: 1, pp 11-15

Chats0

TLDR

Evidence that leads to the proposal that during local injury, MSCs are released from their perivascular location, become activated, and establish a regenerative microenvironment by secreting bioactive molecules and regulating the local immune response is discussed.

About:

This article is published in Cell Stem Cell.The article was published on 2011-07-08 and is currently open access. It has received 1402 citations till now. The article focuses on the topics: Mesenchymal stem cell.

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Regulation of immune responses by extracellular vesicles

Paul D. Robbins, +1 more

- 01 Mar 2014 -

Nature Reviews Immunology

TL;DR: Given the tremendous therapeutic potential of extracellular vesicles, this Review focuses on their role in modulating immune responses, as well as their potential therapeutic applications.

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Mesenchymal stem cells: immune evasive, not immune privileged

James A. Ankrum, +2 more

- 01 Mar 2014 -

Nature Biotechnology

TL;DR: Protecting MSCs from immune detection and prolonging their persistence in vivo may improve clinical outcomes and prevent patient sensitization toward donor antigens.

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Concise Review: MSC-Derived Exosomes for Cell-Free Therapy

Donald G. Phinney, +1 more

- 01 Apr 2017 -

Stem Cells

TL;DR: T careful attention to detail in producing MSC exosomes may provide a new therapeutic paradigm for cell‐free MSC‐based therapies with decreased risk.

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The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine

Paolo Bianco, +6 more

- 01 Jan 2013 -

Nature Medicine

TL;DR: Significant ambiguities still plague the field regarding the nature, identity, function, mode of isolation and experimental handling of MSCs, which have a major impact on their envisioned therapeutic use.

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Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine

Matthew B. Murphy, +2 more

- 01 Nov 2013 -

Experimental and Molecular Medicine

TL;DR: Allogeneic MSC treatments, categorized as a drug by regulatory agencies, have been widely pursued, but new studies demonstrate the efficacy of autologous MSC therapies, even for individuals affected by a disease state.

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References

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Multilineage Potential of Adult Human Mesenchymal Stem Cells

Mark F. Pittenger, +9 more

- 02 Apr 1999 -

Science

TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.

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Mesenchymal stem cells

Arnold I. Caplan

- 01 Sep 1991 -

Journal of Orthopaedic Research

TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.

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Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues

Darwin J. Prockop

- 04 Apr 1997 -

Science

TL;DR: Marrow stromal cells present an intriguing model for examining the differentiation of stem cells and have several characteristics that make them potentially useful for cell and gene therapy.

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Journal ArticleDOI

Human mesenchymal stem cells modulate allogeneic immune cell responses

Sudeepta Aggarwal, +1 more

- 15 Feb 2005 -

Blood

TL;DR: Insight is offered into the interactions between allogeneic MSCs and immune cells and mechanisms likely involved with the in vivo MSC-mediated induction of tolerance that could be therapeutic for reduction of GVHD, rejection, and modulation of inflammation.

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