The N-end rule pathway and regulation by proteolysis
Citations
547 citations
Cites background from "The N-end rule pathway and regulati..."
...Other recent studies demonstrate that Nt-acetylated N-termini may act as proteasomal degradation signals, decreasing protein half-life and being part of the N-end rule pathway [75,76]....
[...]
480 citations
456 citations
394 citations
Cites background from "The N-end rule pathway and regulati..."
...…(Hoege et al. 2002) and histone H2B (Robzyk et al. 2000), but forms polyubiquitin chains in the context of the N-end rule (Dohmen et al. 1991), a conserved pathway that relates protein stability to the identity of the amino terminal residue (Varshavsky 1992; Varshavsky 2011; Tasaki et al. 2012)....
[...]
...These pathways mediate major regulatory events in many eukaryotes, such as the sensing of oxygen and nitric oxide levels (Licausi et al. 2011; Varshavsky 2011)....
[...]
...The first systematically studied and perhaps most surprising degrons are determined by the N-terminal amino acid residue of the substrate protein (Bachmair et al. 1986; Varshavsky 2011)....
[...]
...Rather, destabilizing N-terminal residues are formed as a result of endoproteolytic cleavage by proteases such as separase (see below), or other post-translational events (Varshavsky 2011)....
[...]
386 citations
Cites background from "The N-end rule pathway and regulati..."
...There it is responsible for ubiquitination of substrates containing a degradation signal (degron) composed of an N-terminal type 1 destabilizing residue (Arg, Lys, His) or type 2 destabilizing residues (Leu, Phe, Trp, Tyr or Ile) respectively, an internal lysine residue and an unstructured N-terminal extension [85,86]....
[...]
References
[...]
7,888 citations
3,787 citations
"The N-end rule pathway and regulati..." refers background in this paper
...enzymatically and functionally distinct from the largely posttranslational acetylation of internal residues in many proteins.(103,104) Nt-acetylation and Figure 2....
[...]
2,359 citations
2,177 citations
1,902 citations