The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
Citations
1,984 citations
Cites background from "The NAD+-Dependent Deacetylase SIRT..."
...Mammalian SIRT1, an NAD+-dependent deacetylase, has been recently identified as a novel regulator of circadian gene expression (242, 243)....
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1,765 citations
Cites background from "The NAD+-Dependent Deacetylase SIRT..."
...For example, is SIRT1 induced in liver by fasting or by CR? Are earlier studies on SIRT1 now more difficult to interpret given that we know SIRT1 and its regulator, Nampt, are key components of the circadian clock that vary over a 12-h cycle (51, 53, 291, 292)? NAD+ is an important physiological regulator of sirtuins, even in mitochondria (44), yet it is still not clear how NAD+ is synthesized in various cellular compartments....
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1,674 citations
Cites background from "The NAD+-Dependent Deacetylase SIRT..."
...The ratio of NAD+ to NADH influences binding of NPAS2:BMAL1 and CLOCK:BMAL1 to DNA in vitro, suggesting one way in which NAD could interact with clock components (Rutter et al. 2001)....
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...F or p er so na l u se o nl y. REV-ERBsRRE Bmal1 RORs REV-ERBs CRYs PERs BMAL1 CLOCK BMAL1 CLOCK E-box Rev-erbα RORs E-box Rorα E-box Cry1/Cry2 E-box Per1/Per2 PER CRY CK1ε/δ PER CRY CK1ε/δ E-box Ccg Clock outputs/ rhythmic biological processes CK1 β-TrCP SCF Proteosome Nuclear translocation Repression +Ub 26S SCF FBXL3 AMPK +Ub 26S C Y T O P L A S M N U C L E U S Figure 1 The molecular mechanism of the circadian clock in mammals....
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...HNF4α is responsive to glucocorticoids (Reddy et al. 2007), contains E-boxes, which may allow for transcriptional control by CLOCK:BMAL1 (Reddy et al. 2007), and can interact with PER2 (Schmutz et al. 2010)....
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...NAD levels exhibit circadian oscillations in the liver, likely owing to transcriptional regulation of nicotinamide phosphoribosyltransferase (Nampt, encoding the rate-limiting enzyme in the NAD+ salvage pathway) by CLOCK:BMAL1 (Nakahata et al. 2009, Ramsey et al. 2009)....
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...Other feedback loops involve the PAR-bZip family members, DBP, HLF, and TEF; the bZip protein, E4BP4 (Nfil3); and the bHLH proteins, DEC1 and DEC2 (Bhlhb2, Bhlhb3), all of which are transcriptional targets of CLOCK-BMAL1 (Gachon 2007, Lowrey & Takahashi 2004, Takahashi et al. 2008)....
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1,538 citations
1,538 citations
References
10,046 citations
"The NAD+-Dependent Deacetylase SIRT..." refers background in this paper
...The remodeling of chromatin is largely elicited by enzyme-catalyzed posttranslational modifications of the core histone N-terminal tails (Kouzarides, 2007; Li et al., 2007a; Peterson and Laniel, 2004; Strahl and Allis, 2000)....
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...Unique combinations of these modifications, for which the ‘‘histone code’’ hypothesis has been formulated (Strahl and Allis, 2000), induce conformational changes of chromatin, rendering it permissive to transcription, silencing, DNA replication, and repair (Cheung et al., 2000a; Kouzarides, 2007; Kurdistani and Grunstein, 2003; Li et al., 2007a; Strahl and Allis, 2000)....
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...…hypothesis has been formulated (Strahl and Allis, 2000), induce conformational changes of chromatin, rendering it permissive to transcription, silencing, DNA replication, and repair (Cheung et al., 2000a; Kouzarides, 2007; Kurdistani and Grunstein, 2003; Li et al., 2007a; Strahl and Allis, 2000)....
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8,265 citations
"The NAD+-Dependent Deacetylase SIRT..." refers background in this paper
...The remodeling of chromatin is largely elicited by enzyme-catalyzed posttranslational modifications of the core histone N-terminal tails (Kouzarides, 2007; Li et al., 2007a; Peterson and Laniel, 2004; Strahl and Allis, 2000)....
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...Unique combinations of these modifications, for which the ‘‘histone code’’ hypothesis has been formulated (Strahl and Allis, 2000), induce conformational changes of chromatin, rendering it permissive to transcription, silencing, DNA replication, and repair (Cheung et al., 2000a; Kouzarides, 2007; Kurdistani and Grunstein, 2003; Li et al., 2007a; Strahl and Allis, 2000)....
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...Unique combinations of these modifications, for which the ‘‘histone code’’ hypothesis has been formulated (Strahl and Allis, 2000), induce conformational changes of chromatin, rendering it permissive to transcription, silencing, DNA replication, and repair (Cheung et al., 2000a; Kouzarides, 2007;…...
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...…hypothesis has been formulated (Strahl and Allis, 2000), induce conformational changes of chromatin, rendering it permissive to transcription, silencing, DNA replication, and repair (Cheung et al., 2000a; Kouzarides, 2007; Kurdistani and Grunstein, 2003; Li et al., 2007a; Strahl and Allis, 2000)....
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...Histone acetylation is recognized as one of the most prominent epigenetic marks leading to activation of gene expression (Strahl and Allis, 2000)....
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3,740 citations
"The NAD+-Dependent Deacetylase SIRT..." refers background in this paper
...…(Brunet et al., 2004; Luo et al., 2001), promotes mobilization of fat from white adipose tissues, an event that contributes to extending the life span (Picard et al., 2004), and mediates the metabolism of energy sources in metabolically active tissues (Lagouge et al., 2006; Rodgers et al., 2005)....
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..., 2004), and mediates the metabolism of energy sources in metabolically active tissues (Lagouge et al., 2006; Rodgers et al., 2005)....
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3,424 citations
"The NAD+-Dependent Deacetylase SIRT..." refers background in this paper
...The remodeling of chromatin is largely elicited by enzyme-catalyzed posttranslational modifications of the core histone N-terminal tails (Kouzarides, 2007; Li et al., 2007a; Peterson and Laniel, 2004; Strahl and Allis, 2000)....
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...…clocks (McNamara et al., 2001; Yin et al., 2007), and since SIRT1 has been found to control a number of nuclear receptors (see for example Li et al., 2007b), it is reasonable to speculate that the CLOCK-SIRT1 interaction described in this study represents a key event in the processes of…...
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...…hypothesis has been formulated (Strahl and Allis, 2000), induce conformational changes of chromatin, rendering it permissive to transcription, silencing, DNA replication, and repair (Cheung et al., 2000a; Kouzarides, 2007; Kurdistani and Grunstein, 2003; Li et al., 2007a; Strahl and Allis, 2000)....
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...…et al., 2001; Vaziri et al., 2001), FOXO3 (Brunet et al., 2004; Motta et al., 2004), PGC-1a (Nemoto et al., 2005; Rodgers et al., 2005), and LXR (Li et al., 2007a), are regulated by SIRT1-mediated deacetylation, stressing the pivotal function that this regulator plays in cellular control and…...
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...…groups of specific lysine residues in the N termini of core histones is generally associated with transcription activity, as it is thought to induce an open chromatin conformation that allows the transcription machinery access to promoters (Cheung et al., 2000a; Li et al., 2007a; Struhl, 1998)....
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3,252 citations
"The NAD+-Dependent Deacetylase SIRT..." refers background or methods in this paper
..., 2006), and also because SIRT1 deacetylase function was described to be targeted to these lysines (Imai et al., 2000)....
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...We reasoned that CLOCK-mediated acetylation, and thereby transcriptional activation, could be counterbalanced by transcriptional silencing induced by NAD+-dependent HDACs (Imai et al., 2000; Landry et al., 2000)....
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...This assay likely reflects the intracellular relative concentrations of NAD+ and NAM, or of yet undefined circadian metabolites, whose ratio determines SIRT1 activity (Imai et al., 2000; Luo et al., 2001)....
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...We reasoned that CLOCK-mediated acetylation, and thereby transcriptional activation, could be counterbalanced by transcriptional silencing induced by NAD-dependent HDACs (Imai et al., 2000; Landry et al., 2000)....
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...We analyzed the acetylation at Lys9 and Lys14 of histone H3 because we had previously found these to be preferential sites of CLOCK’s HAT activity (Doi et al., 2006), and also because SIRT1 deacetylase function was described to be targeted to these lysines (Imai et al., 2000)....
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