The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes.
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TLDR
Some of the reasons for failure are reviewed, delineating both scientific and technical realities, some unique to the CNS, that have contributed to this, to suggest some changes that may improve outcomes in future CNS‐targeted drug discovery and development efforts.About:
This article is published in Neuropharmacology.The article was published on 2017-07-01 and is currently open access. It has received 207 citations till now.read more
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Alzheimer's disease drug development pipeline: 2022
Jeffrey L. Cummings,Garam Lee,Pouyan Nahed,Mina Esmail Zadeh Nojoo Kambar,Kate Zhong,Jorge Fonseca,Kazem Taghva +6 more
TL;DR: The AD drug development pipeline has agents representing a substantial array of treatment mechanisms and targets, and advances in drug design, outcome measures, use of biomarkers, and trial conduct promise to accelerate the delivery of new and better treatments for patients with AD.
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Opportunities and challenges in modeling human brain disorders in transgenic primates
Charles Jennings,Rogier Landman,Rogier Landman,Yang Zhou,Jitendra Sharma,Julia B. Hyman,J. Anthony Movshon,Zilong Qiu,Angela C. Roberts,Anna W. Roe,Xiaoqin Wang,Huihui Zhou,Liping Wang,Feng Zhang,Feng Zhang,Robert Desimone,Guoping Feng,Guoping Feng +17 more
TL;DR: The main focus is on the creation of new primate disease models for understanding the pathological mechanisms of brain disorders and for developing new approaches to effective treatment, but it is emphasized that primate genetic models have great potential to address many fundamental questions about brain function.
Journal ArticleDOI
CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes
Lilianne Barbar,Tanya Jain,Matthew Zimmer,I. A. Kruglikov,Jessica S. Sadick,Minghui Wang,Kriti Kalpana,Indigo V.L. Rose,Suzanne R. Burstein,Tomasz Rusielewicz,Madhura P. Nijsure,Kevin A. Guttenplan,Angelique di Domenico,Gist F. Croft,Bin Zhang,Hiroko Nobuta,Jean M. Hébert,Shane A. Liddelow,Valentina Fossati +18 more
TL;DR: It is shown that CD49f is a novel marker for human astrocytes, expressed in fetal and adult brains from healthy and diseased individuals, and that conditioned medium from human reactive A1-like astroCytes is toxic to human and rodent neurons.
Journal ArticleDOI
High-Throughput Screening Platforms in the Discovery of Novel Drugs for Neurodegenerative Diseases
TL;DR: A review of the increasing role of HTS in contemporary drug discovery processes, in particular for NDDs, and evaluate the criteria underlying its successful application is presented in this paper.
Journal ArticleDOI
The Interstitial System of the Brain in Health and Disease
TL;DR: The goal of this review is to confer recent advances in the understanding of the brain ISS, including its structure, function, and the various processes mediating or disrupting ISF drainage in physiological and pathological conditions.
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