The neural crest.
Roberto Mayor,Eric Theveneau +1 more
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TLDR
An overview of neural crest formation, differentiation and migration is provided, highlighting the molecular mechanisms governing NC migration.Abstract:
The neural crest (NC) is a highly migratory multipotent cell population that forms at the interface between the neuroepithelium and the prospective epidermis of a developing embryo. Following extensive migration throughout the embryo, NC cells eventually settle to differentiate into multiple cell types, ranging from neurons and glial cells of the peripheral nervous system to pigment cells, fibroblasts to smooth muscle cells, and odontoblasts to adipocytes. NC cells migrate in large numbers and their migration is regulated by multiple mechanisms, including chemotaxis, contact-inhibition of locomotion and cell sorting. Here, we provide an overview of NC formation, differentiation and migration, highlighting the molecular mechanisms governing NC migration.read more
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The front and rear of collective cell migration
TL;DR: The recent studies have described how leader cells at the front of cell groups drive migration and have highlighted the importance of follower cells and cell-cell communication, both between followers and between follower and leader cells, to improve the efficiency of collective movement.
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Rho GTPase signalling in cell migration.
TL;DR: Recent advances in understanding of how Rho GTPases contribute to different types of migration are reviewed, comparing lamellipodium-driven versus bleb-driven migration modes and how cells migrate across the endothelium is described.
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The melanocyte lineage in development and disease.
TL;DR: This review discusses melanocyte development and differentiation, melanocyte stem cells, and the role of the melanocyte lineage in diseases such as melanoma.
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Tissue mechanics regulate brain development, homeostasis and disease
TL;DR: The roles of cell and tissue mechanics in brain development, homeostasis and neural degeneration, as well as in brain cancer, are reviewed.
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Origin and differentiation of vascular smooth muscle cells.
TL;DR: In this paper, the origin and differentiation of vascular smooth muscle cells (SMCs) from stem/progenitor cells during cardiovascular development and in the adult are reviewed. And the authors highlight the environmental cues and signalling pathways that control phenotypic modulation within the vasculature.
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The neural crest
TL;DR: The Neural Crest is a structure unique to the vertebrate embryo, which has only a transient existence in early embryonic life as discussed by the authors, and the ontogeny of the neural crest embodies the most important issues in developmental biology.
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Metastasis: from dissemination to organ-specific colonization
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