The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models
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"The neurosteroid allopregnanolone p..." refers background in this paper
...The phagophore sequesters cytosolic materials and organelles to form a double-membrane vesicle called an autophagosome (AP) [6]....
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2,708 citations
"The neurosteroid allopregnanolone p..." refers background in this paper
...SQSTM1 (sequestosome 1) is a protein that is incorporated into completed APs and accumulates when autophagy is impaired [22,23]....
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...Levels of SQSTM1 inversely correlate with autophagy activity, and when autophagy is inhibited, SQSTM1 accumulates [22,23]....
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2,395 citations
"The neurosteroid allopregnanolone p..." refers background in this paper
...Increased intraocular pressure (IOP) is a major risk factor for glaucoma [3]....
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1,534 citations
"The neurosteroid allopregnanolone p..." refers background in this paper
...Under pathological conditions, there is a constitutively high level of SQSTM1, which can lead to the accumulation of damaged mitochondria and subsequent ROS production [29]....
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