The nuclear epidermal growth factor receptor signaling network and its role in cancer
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775 citations
Cites background from "The nuclear epidermal growth factor..."
...Translocation of full-length EGFR into the nucleus has long been documented and the functions it has at this location have been extensively investigated; we therefore refer the readers to detailed reviews (Brand et al., 2011; Han and Lo, 2012)....
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Cites background from "The nuclear epidermal growth factor..."
...A full-length form of cell surface EGFR has been shown to be translocated to the nucleus, where evidence suggests that it is involved in transcriptional regulation, cell proliferation, DNA replication, DNA repair, and chemo- and radio-resistance [43-48]....
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References
10,791 citations
"The nuclear epidermal growth factor..." refers result in this paper
...Based on previous reports demonstrating that basal type breast cancers overexpress EGFR and B-Myb(Nielsen et al., 2004; Sorlie et al., 2001), Hanada et al....
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2,657 citations
"The nuclear epidermal growth factor..." refers background in this paper
...In the 1980s, the EGFR was cloned and sequenced and subsequently recognized as a receptor tyrosine kinase (RTK) (Ullrich et al., 1984)....
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2,562 citations
"The nuclear epidermal growth factor..." refers result in this paper
...Based on previous reports demonstrating that basal type breast cancers overexpress EGFR and B-Myb(Nielsen et al., 2004; Sorlie et al., 2001), Hanada et al....
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2,109 citations
"The nuclear epidermal growth factor..." refers background in this paper
...In the early 1960s Stanley Cohen isolated and characterized a protein from the salivary gland that induced eye-lid opening and tooth eruption in newborn mice(Cohen, 1962)....
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1,051 citations
"The nuclear epidermal growth factor..." refers background in this paper
...Nuclear expression of EGFR was further detected in other cell types and tissues, such as mouse uterus, developing mouse embryos, rat liver, placentas, thyroids and immortalized epithelial cells of ovary and kidney origins(Cao et al., 1995; Lin et al., 2001; Marti et al., 2001)....
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...Since its first identification of its role as a transcription factor in 2001(Lin et al., 2001), EGFR has led the way in discovery of various other nuclear localized RTKs, including HER2(Wang et al....
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...High levels of EGFR were also found in the nuclei of many tumors, including those of skin, breast, bladder, cervix, adrenocortical carcinoma, thyroid and oral cavity (Kamio et al., 1990; Lin et al., 2001; Lipponen & Eskelinen, 1994; Lo et al., 2005a; Lo et al., 2005b; Marti et al., 2001; Psyrri et al., 2005)....
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...The nuclear counterpart of EGFR appears to be the full-length receptor and likely, in the phosphorylated form, as shown by a number of studies(Cao et al., 1995; Cordero et al., 2002; Dittmann et al., 2005a; Lin et al., 2001; Lo et al., 2005a; Lo et al., 2005b)....
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...EGFR has now been identified as a transcriptional co-activator for seven cancer promoting genes: cyclin D1(Lin et al., 2001), nitric oxide synthase (iNOS)(Lo et al....
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