Journal ArticleDOI
The obstetric origins of health for a lifetime
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TLDR
According to the developmental model variations in the processes of development program the function of a few key systems that are linked to disease, including the immune system, antioxidant defenses, inflammatory responses, and the number and quality of stem cells.Abstract:
There is a new "developmental" model for the origins of a wide range of chronic diseases. Under this model the causes to be identified are linked to normal variations in fetoplacental development. These variations are thought to lead to variations in the supply of nutrients to the baby that permanently alter gene expression, a process known as "programming." According to the developmental model variations in the processes of development program the function of a few key systems that are linked to disease, including the immune system, antioxidant defenses, inflammatory responses, and the number and quality of stem cells.read more
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Journal ArticleDOI
Every Newborn: progress, priorities, and potential beyond survival
Joy E Lawn,Joy E Lawn,Hannah Blencowe,Shefali Oza,Danzhen You,Anne C C Lee,Anne C C Lee,Peter Waiswa,Peter Waiswa,Marek Lalli,Zulfiqar A Bhutta,Aluísio J D Barros,Parul Christian,Colin Mathers,Simon Cousens +14 more
TL;DR: National targets for 2035 are proposed for stillbirths and neonatal deaths, compatible with the under-5 mortality targets of no more than 20 per 1000 livebirths, and targets for 2030 are given.
Journal ArticleDOI
Origins of lifetime health around the time of conception: causes and consequences.
Tom P. Fleming,Adam J. Watkins,Miguel A. Velazquez,John C. Mathers,Andrew M. Prentice,Judith Stephenson,Mary Barker,Mary Barker,Richard Saffery,Chittaranjan S. Yajnik,Judith J. Eckert,Mark A. Hanson,Mark A. Hanson,Terrence Forrester,Peter D. Gluckman,Peter D. Gluckman,Keith M. Godfrey,Keith M. Godfrey +17 more
TL;DR: It is proposed that the evidence for periconceptional effects on lifetime health is now so compelling that it calls for new guidance on parental preparation for pregnancy, beginning before conception, to protect the health of offspring.
Journal ArticleDOI
Pathophysiology of placental-derived fetal growth restriction.
Graham J. Burton,Eric Jauniaux +1 more
TL;DR: In this article, the authors found that placenta-related fetal growth restriction arises primarily due to deficient remodeling of the uterine spiral arteries supplying the placentas during early pregnancy, leading to selective suppression of protein synthesis and reduced cell proliferation.
Journal ArticleDOI
Placental Origins of Chronic Disease.
TL;DR: The complex relationships between the placental phenotype and developmental programming of chronic disease in the offspring are explored, offering a new approach to the prevention of disorders such as cardiovascular disease, diabetes, and obesity, which are reaching epidemic proportions.
Journal ArticleDOI
Developmental origins of health and disease
TL;DR: An important hypothesis is raised that many an adult disease may have its origin during development in periconceptional, embryonic, fetal and early neonatal life and adult disease is probably a complex interplay of genotypic variation and environmental factors.
References
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Journal ArticleDOI
Fetal origins of coronary heart disease
TL;DR: The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease.
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Weight in infancy and death from ischaemic heart disease.
TL;DR: Measurements that promote prenatal and postnatal growth may reduce deaths from ischaemic heart disease and may be especially important in boys who weigh below 7.5 pounds (3.4 kg) at birth.
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Fetal and infant growth and impaired glucose tolerance at age 64.
C. N. Hales,David J.P. Barker,Penelope M.S. Clark,Lorna Cox,Caroline H.D. Fall,Clive Osmond,P D Winter +6 more
TL;DR: Reduced growth in early life is strongly linked with impaired glucose tolerance and non-insulin dependent diabetes and reduced early growth is also related to a raised plasma concentration of 32-33 split proinsulin, which is interpreted as a sign of beta cell dysfunction.
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Fetal origins of adult disease: strength of effects and biological basis
TL;DR: The combination of small size at birth and during infancy, followed by accelerated weight gain from age 3 to 11 years, predicts large differences in the cumulative incidence of CHD, type 2 diabetes and hypertension.
Journal ArticleDOI
Fetal and placental size and risk of hypertension in adult life.
TL;DR: For the first time, the intrauterine environment has an important effect on blood pressure and hypertension in adults and the highest blood pressures occurred in men and women who had been small babies with large placentas.