The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice
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356 citations
Cites background from "The oral administration of trans-ca..."
...This was observed in mice after oral administration of BCP, in which licking and jumping latency in the hot plate test was increased, whereas pain feeling in the formalin test was attenuated [53]....
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...[53] reported a decreased level of IL- 1β in the injured sciatic nerve after BCP treatment, in a model of chronic pain....
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221 citations
172 citations
Cites background from "The oral administration of trans-ca..."
...+e authors evaluated the potential mechanisms responsible for the substance’s properties and found that the analgesic effect was reversed by several types of antagonists [203], thus indicating the involvement of both the opioid and endocannabinoid system [204]....
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139 citations
Cites background or methods from "The oral administration of trans-ca..."
...The additional μ-opioid receptor activity [79,80] and potent antagonist activity on homomeric nicotinic acetylcholine receptors ( 7-nAChRs) support its potent antiinflammatory activity....
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...[79] showed that BCP treatment significantly minimized the pain evaluated in murine models of acute induced by hot plate test (thermal nociception) and the formalin test (inflammatory pain) and chronic pain induced by chronic constriction injury of the sciatic nerve induced hyper-nociception was measured by the hot plate and von Frey tests....
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...Based on the available studies demonstrating the dual targeting of CB2 receptors and opioid receptors, and synergistic action of BCP with other agents, the combination appears a promising candidate for the treatment of chronic pain due to high potency and comparable safety and efficacy along with low adverse effects profiles [79,80, 91]....
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...BCP has been reported to exert strong anti-inflammatory effects in numerous in vitro and in vivo studies [6,71,79,88,89], which positively contribute to influence several of its biological and therapeutic activities in diseases where low grade and long term inflammation play an important role in etiopathogensis [75,90]....
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...Correspondingly, BCP has shown substantial maximal efficacy in neuropathic pain and found superior over synthetic CB2 ligands and appear beneficial as adjuvant with opioid analgesics and other drugs [79, 80, 93]....
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111 citations
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