The Organization of Mitochondrial Quality Control and Life Cycle in the Nervous System In Vivo in the Absence of PINK1.
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Cites background from "The Organization of Mitochondrial Q..."
...In Drosophila, loss of PINK1 decreases the membrane potential of axonal mitochondria and causes structural abnormalities to the organelles (Devireddy et al., 2015), but knockout of PINK1 and Parkin in rodent models causes little or no neurodegeneration....
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228 citations
Cites background or result from "The Organization of Mitochondrial Q..."
...For example, the bulk turnover of mitochondria via mitophagy may occur specifically within the soma (Cai et al., 2012; Devireddy et al., 2015)....
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...These results further support the hypothesis that autophagy in primary neurons is highly compartmentalized (Maday and Holzbaur, 2014; Devireddy et al., 2015)....
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227 citations
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References
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"The Organization of Mitochondrial Q..." refers background in this paper
...In addition, Drosophila is genetically tractable and has well-established genetic procedures for generating gene deletion mutants (St Johnston, 2013), and for manipulating gene expression via RNAi knockdown or overexpression in specific tissues using UAS-Gal4 system (Brand and Perrimon, 1993)....
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4,922 citations
"The Organization of Mitochondrial Q..." refers background in this paper
...Genes encoding parkin, a cytosolic ubiquitin ligase, and PINK1, a mitochondrial kinase, are originally identified to be associated with Parkinson’s disease (PD), and their mutations have been shown to cause the autosomal recessive form of familial PD (Kitada et al., 1998; Valente et al., 2004)....
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4,282 citations
"The Organization of Mitochondrial Q..." refers background in this paper
...This causes additional damage to proteins, lipids, and nucleic acids, eventually leading to gross oxidative stress (Turrens, 2003)....
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...During the process of ETC, superoxide radicals (O2) can be generated at complexes I and III, by anomalous transfer of electrons to oxygen (Turrens, 2003)....
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...Oxidative stress is thought to play an important role in age-related progressive neurodegenerative diseases such as Parkinson’s disease (PD) and Amyotrophic lateral sclerosis (ALS) (Turrens, 2003; Barnham et al., 2004)....
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4,195 citations
"The Organization of Mitochondrial Q..." refers methods in this paper
...Mitochondrial volume was determined in CBs by setting the intensity threshold on Z-slices using 3D object counter (Bolte and Cordelières, 2006) and 3D ROI manager (Ollion et al....
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...Mitochondrial volume was determined in CBs by setting the intensity threshold on Z-slices using 3D object counter (Bolte and Cordelières, 2006) and 3D ROI manager (Ollion et al., 2013) plugins in ImageJ....
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