The organization of the human cerebral cortex estimated by intrinsic functional connectivity
B.T. Thomas Yeo,Fenna M. Krienen,Jorge Sepulcre,Jorge Sepulcre,Mert R. Sabuncu,Mert R. Sabuncu,Danial Lashkari,Marisa O. Hollinshead,Marisa O. Hollinshead,Joshua L. Roffman,Jordan W. Smoller,Lilla Zöllei,Jonathan R. Polimeni,Bruce Fischl,Bruce Fischl,Hesheng Liu,Randy L. Buckner +16 more
Reads0
Chats0
TLDR
In this paper, the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI data from 1,000 subjects and a clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex.Abstract:
Information processing in the cerebral cortex involves interactions among distributed areas. Anatomical connectivity suggests that certain areas form local hierarchical relations such as within the visual system. Other connectivity patterns, particularly among association areas, suggest the presence of large-scale circuits without clear hierarchical relations. In this study the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI. Data from 1,000 subjects were registered using surface-based alignment. A clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex. The results revealed local networks confined to sensory and motor cortices as well as distributed networks of association regions. Within the sensory and motor cortices, functional connectivity followed topographic representations across adjacent areas. In association cortex, the connectivity patterns often showed abrupt transitions between network boundaries. Focused analyses were performed to better understand properties of network connectivity. A canonical sensory-motor pathway involving primary visual area, putative middle temporal area complex (MT+), lateral intraparietal area, and frontal eye field was analyzed to explore how interactions might arise within and between networks. Results showed that adjacent regions of the MT+ complex demonstrate differential connectivity consistent with a hierarchical pathway that spans networks. The functional connectivity of parietal and prefrontal association cortices was next explored. Distinct connectivity profiles of neighboring regions suggest they participate in distributed networks that, while showing evidence for interactions, are embedded within largely parallel, interdigitated circuits. We conclude by discussing the organization of these large-scale cerebral networks in relation to monkey anatomy and their potential evolutionary expansion in humans to support cognition.read more
Citations
More filters
Journal ArticleDOI
The WU-Minn Human Connectome Project: An Overview
TL;DR: Progress made during the first half of the Human Connectome Project project in refining the methods for data acquisition and analysis provides grounds for optimism that the HCP datasets and associated methods and software will become increasingly valuable resources for characterizing human brain connectivity and function, their relationship to behavior, and their heritability and genetic underpinnings.
Journal ArticleDOI
Functional network organization of the human brain
Jonathan D. Power,Alexander L. Cohen,Steven M. Nelson,Gagan S. Wig,Kelly Anne Barnes,Jessica A. Church,Alecia C. Vogel,Timothy O. Laumann,F.M. Miezin,Bradley L. Schlaggar,Steven E. Petersen +10 more
TL;DR: In this article, the authors studied functional brain organization in healthy adults using resting state functional connectivity MRI and proposed two novel brain wide graphs, one of 264 putative functional areas, the other a modification of voxelwise networks that eliminates potentially artificial short-distance relationships.
Journal ArticleDOI
A multi-modal parcellation of human cerebral cortex
Matthew F. Glasser,Timothy S. Coalson,Emma C. Robinson,Emma C. Robinson,Carl D. Hacker,John W. Harwell,Essa Yacoub,Kamil Ugurbil,Jesper L. R. Andersson,Christian F. Beckmann,Mark Jenkinson,Stephen Smith,David C. Van Essen +12 more
TL;DR: Using multi-modal magnetic resonance images from the Human Connectome Project and an objective semi-automated neuroanatomical approach, 180 areas per hemisphere are delineated bounded by sharp changes in cortical architecture, function, connectivity, and/or topography in a precisely aligned group average of 210 healthy young adults.
Journal ArticleDOI
Methods to detect, characterize, and remove motion artifact in resting state fMRI
Jonathan D. Power,Anish Mitra,Timothy O. Laumann,Abraham Z. Snyder,Bradley L. Schlaggar,Steven E. Petersen +5 more
TL;DR: It is found that motion-induced signal changes are often complex and variable waveforms, often shared across nearly all brain voxels, and often persist more than 10s after motion ceases, which increase observed RSFC correlations in a distance-dependent manner.
Journal ArticleDOI
Dynamic functional connectivity: Promise, issues, and interpretations
R. Matthew Hutchison,Thilo Womelsdorf,Elena A. Allen,Elena A. Allen,Peter A. Bandettini,Vince D. Calhoun,Vince D. Calhoun,Maurizio Corbetta,Maurizio Corbetta,Stefania Della Penna,Jeff H. Duyn,Gary H. Glover,Javier Gonzalez-Castillo,Daniel A. Handwerker,Shella D. Keilholz,Vesa Kiviniemi,David A. Leopold,Francesco de Pasquale,Olaf Sporns,Martin Walter,Martin Walter,Catie Chang +21 more
TL;DR: Emerging evidence suggests that dynamic FC metrics may index changes in macroscopic neural activity patterns underlying critical aspects of cognition and behavior, though limitations with regard to analysis and interpretation remain.
References
More filters
Journal ArticleDOI
Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems
TL;DR: It is demonstrated that the neuroanatomical substrates of human attention persist in the absence of external events, reflected in the correlation structure of spontaneous activity.
Journal ArticleDOI
The Global Signal and Observed Anticorrelated Resting State Brain Networks
TL;DR: Several characteristics of anticorrelated networks including their spatial distribution, cross-subject consistency, presence with modified whole brain masks, and existence before global regression are not attributable to global signal removal and therefore suggest a biological basis.
Journal ArticleDOI
Intrinsic functional architecture in the anaesthetized monkey brain.
Justin L. Vincent,Gaurav H. Patel,Michael D. Fox,Abraham Z. Snyder,Justin T. Baker,D. C. Van Essen,John M. Zempel,Lawrence H. Snyder,Maurizio Corbetta,Marcus E. Raichle +9 more
TL;DR: This work demonstrates coherent spontaneous fluctuations within three well known systems (oculomotor, somatomotor and visual) and the ‘default’ system, a set of brain regions thought by some to support uniquely human capabilities.
Journal ArticleDOI
Unbiased Average Age-Appropriate Atlases for Pediatric Studies
Vladimir S. Fonov,Alan C. Evans,Kelly N. Botteron,C. Robert Almli,Robert C. McKinstry,D. Louis Collins +5 more
TL;DR: The methods used to create unbiased, age-appropriate MRI atlas templates for pediatric studies that represent the average anatomy for the age range of 4.5-18.5 years are presented, while maintaining a high level of anatomical detail and contrast.