The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi.
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Cites background from "The origin of GPCRs: identification..."
...The 748 human GPCR (683 of the Rhodopsin class, 33 Adhesion, 22 Glutamate, and 10 Frizzled) (952) are all characterized by multiple transmembrane helical domains....
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Cites background from "The origin of GPCRs: identification..."
...Recently, Adhesion GPCRs with short extracellular regions have been identified in several basal fungi, indicating that the Adhesion family is likely to have evolved before the split of unikonts from the common ancestor of eukaryotes about 1275 million years ago (Krishnan et al., 2012)....
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...…domains, with as primary examples the emergence of the GPCR proteolysis site (GPS) and Calx_beta domains in the unicellular filasterean C. owczarzaki and the appearance of EGF_CA domains in free-living unicellular organisms, such as the choanoflagellate Salpingoeca rosetta (Krishnan et al., 2012)....
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...Adhesion GPCRs, like other GPCR families, were proposed to have evolved from a common ancestor with the ancient cAMP receptors (Nordstrom et al., 2011; Krishnan et al., 2012) typically found in Dictyostelium discoideum....
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...However, there are also Adhesion GPCR genes in the genomes of choanoflagellates and fungi that cannot be classified according to the specific metazoan families (Krishnan et al., 2012)....
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...…(Kamesh et al., 2008; Nordstrom et al., 2008), primitive animals (Putnam et al., 2007; Nordstrom et al., 2011), the most ancient metazoan phyla (Srivastava et al., 2010), and also in unicellular metazoan relatives, such as Capsaspora owczarzaki and Monosiga brevicollis (Krishnan et al., 2012)....
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336 citations
Cites background from "The origin of GPCRs: identification..."
...GPCRs are seven-pass membrane receptors that can bind to a wide variety of ligands (1) and form the largest family of integral membrane proteins in the human genome (2)....
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References
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"The origin of GPCRs: identification..." refers methods in this paper
...The putative dataset was aligned to the complete Pfam database version 24, which has 11912 families with sensitive HMM models built using HMMER3 software [41]....
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9,415 citations
"The origin of GPCRs: identification..." refers methods in this paper
...The putative dataset was aligned to the complete Pfam database version 24, which has 11912 families with sensitive HMM models built using HMMER3 software [41]....
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8,306 citations