The Pathogenesis of Rift Valley Fever
Tetsuro Ikegami,Shinji Makino +1 more
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TLDR
The pathology of RVF in human patients and several animal models is described, and the role of viral virulence factors and host factors that affect RVFV pathogenesis are summarized.Abstract:
Rift Valley fever (RVF) is an emerging zoonotic disease distributed in sub-Saharan African countries and the Arabian Peninsula. The disease is caused by the Rift Valley fever virus (RVFV) of the family Bunyaviridae and the genus Phlebovirus. The virus is transmitted by mosquitoes, and virus replication in domestic ruminant results in high rates of mortality and abortion. RVFV infection in humans usually causes a self-limiting, acute and febrile illness; however, a small number of cases progress to neurological disorders, partial or complete blindness, hemorrhagic fever, or thrombosis. This review describes the pathology of RVF in human patients and several animal models, and summarizes the role of viral virulence factors and host factors that affect RVFV pathogenesis.read more
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Rift Valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention
TL;DR: This review presents the latest advances in RVF virus research and explains why safe, effective vaccines are still not freely available for protecting humans and livestock against the dramatic consequences of this virus.
Journal ArticleDOI
Rift Valley fever virus
TL;DR: R Rift Valley fever epizootics and epidemics can rapidly overwhelm the capacities of the public health and veterinary medical communities to provide rapid diagnostic testing and adequate medical care for affected humans and other animals, which can number in the tens of thousands.
Journal ArticleDOI
Rift Valley fever virus: A review of diagnosis and vaccination, and implications for emergence in Europe.
Karen L. Mansfield,Ashley C. Banyard,Lorraine M. McElhinney,Nicholas Johnson,Daniel L. Horton,Luis M. Hernández-Triana,Anthony R. Fooks +6 more
TL;DR: The methods available for diagnosis of Rift Valley fever virus infection, the current status of vaccine development and possible implications for RVFV emergence in Europe are discussed.
Journal ArticleDOI
Antiviral Autophagy Restricts Rift Valley Fever Virus Infection and Is Conserved from Flies to Mammals
Ryan H. Moy,Beth Gold,Jerome M. Molleston,Veronica Schad,Kilangsungla Yanger,Mary-Virginia Salzano,Yoshimasa Yagi,Katherine A. Fitzgerald,Ben Z. Stanger,Samantha S. Soldan,Sara Cherry +10 more
TL;DR: It is found that antiviral autophagy was conserved in flies and mammals during infection with Rift Valley fever virus (RVFV), a mosquito-borne virus that causes disease in humans and livestock.
Journal ArticleDOI
Molecular biology and genetic diversity of Rift Valley fever virus
TL;DR: High degree of conservation of genes encoding the virion surface glycoproteins suggests that a single vaccine should protect against all currently circulating RVFV strains, and preservation of the sequence of the RNA-dependent RNA polymerase across viral lineages implies that antiviral drugs targeting the enzyme should be effective against all strains.
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Enzootic hepatitis or rift valley fever. An undescribed virus disease of sheep cattle and man from east africa
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Yi-Li Yang,Luiz F. L. Reis,Jovan Pavlovic,Adriano Aguzzi,R. Schafer,Aseem Kumar,Bryan R.G. Williams,Michel Aguet,Charles Weissmann +8 more
TL;DR: In embryo fibroblasts from Pkr knockout mice, the induction of type I IFN as well as the activation of NF‐kappa B by pIC, were strongly impaired but restored by priming with IFN, suggesting a pIC‐responsive system independent of PKR is induced by IFN.
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Climate and Satellite Indicators to Forecast Rift Valley Fever Epidemics in Kenya
Kenneth J. Linthicum,Assaf Anyamba,Compton J. Tucker,Patrick W. Kelley,Monica F. Myers,Clarence J. Peters +5 more
TL;DR: Analysis of this record and Pacific and Indian Ocean sea surface temperature anomalies, coupled with satellite normalized difference vegetation index data, shows that prediction of Rift Valley fever outbreaks may be made up to 5 months in advance of outbreaks in East Africa.
Journal ArticleDOI
Rift Valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention
TL;DR: This review presents the latest advances in RVF virus research and explains why safe, effective vaccines are still not freely available for protecting humans and livestock against the dramatic consequences of this virus.