The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis
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2,650 citations
Cites background from "The penicillin-binding proteins: st..."
...Transpeptidases that couple branched stem peptides are mechanistically similar to those that couple unbranched stem peptides; however, their substrate specificity is sufficiently different that they only recognize unbranched stem peptides, and some of them are resistant to beta lactams (Rohrer and BergerBachi 2003; Pratt 2008; Sauvage et al. 2008)....
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...…are mechanistically similar to those that couple unbranched stem peptides; however, their substrate specificity is sufficiently different that they only recognize unbranched stem peptides, and some of them are resistant to beta lactams (Rohrer and BergerBachi 2003; Pratt 2008; Sauvage et al. 2008)....
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1,876 citations
Cites background from "The penicillin-binding proteins: st..."
...The crosslinking reactions are catalyzed by the transpeptidase domain of penicillin-binding proteins, enzymes that have been studied extensively, in particular in human pathogenic bacteria (Sauvage et al., 2008)....
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...DD-Endopeptidases hydrolyse the D-Ala-meso-A2pm cross-bridges, which had been formed by DD-transpeptidation in nascent peptidoglycan by the class A and B high-MW penicillin-binding proteins (HMW-PBPs) (Sauvage et al., 2008)....
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...The first one is a multi-modular enzyme described as type-4 PBP (Sauvage et al., 2008) and is not anchored to the cytoplasmic membrane via a transmembrane helix (Gittins et al., 1994; Harris et al., 2002; Stefanova et al., 2003)....
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...These enzymes belong to the type-7 PBPs (Sauvage et al., 2008)....
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...…belong to the low-MW PBPs that share the typical sequence motifs of PBPs and are inhibited by blactams, which are structural analogues of the terminal D-Ala-D-Ala moiety in the pentapeptide donor for a peptidoglycan transpeptidation reaction (Goffin & Ghuysen, 1998; Sauvage et al., 2008)....
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...Structures of DD-carboxypeptidases are reviewed in more detail in another article in this issue (Sauvage et al., 2008)....
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References
3,705 citations
"The penicillin-binding proteins: st..." refers background in this paper
...24 [9] Barrett DS, Chen L, Litterman NK & Walker S (2004) Expression and characterization of the 25 isolated glycosyltransferase module of Escherichia coli PBP1b....
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...It has been suggested that both observed apoenzyme 22 structures may illustrate a conformational sampling of the ‘‘open’’ and ‘‘closed’’ forms that may 23 play a regulatory role in PBP1b catalytic activity....
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...E. coli 21 possesses three class A PBPs. PBP1a and PBP1b are the major transpeptidases-transglycosylases....
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...derivative of PBP1b (82-300) was also produced in the absence of detergent....
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...For example, the fragments M46-D478 and M46-Q423 retain 23% 13 and 13% of the entire PBP1b activity respectively (Terrak, et al., 1999)....
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"The penicillin-binding proteins: st..." refers background in this paper
...24 The N-terminal domain was hypothesized to interact with other proteins (Holtje, 1998) or to 1 serve as a pedestal for PBPs to reach their target (Macheboeuf, et al., 2006)....
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...In class B, 5 the N-terminal domain is believed to play a role in cell morphogenesis by interacting with other 6 proteins involved the cell cycle (Holtje, 1998)....
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...The donor strand can adopt a three- or fourfold 13 rotation axis (Holtje, 1998, Meroueh, et al., 2006) while running along the class A PBP surface....
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