Journal ArticleDOI
The phosphoinositide 3-kinase pathway.
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TLDR
The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.Abstract:
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.read more
Citations
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References
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Journal Article
Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.
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Journal ArticleDOI
PTEN: a tumour suppressor that functions as a phospholipid phosphatase
Tomohiko Maehama,Jack E. Dixon +1 more
TL;DR: The function of PTEN is discussed and how this could be linked to its activity as a tumour suppressor, which is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signalling.
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