The Potential Role of Polyphenols in Oxidative Stress and Inflammation Induced by Gut Microbiota in Alzheimer's Disease.
Reads0
Chats0
TLDR
In this article, a review of the role of polyphenols in AD and other neurodegenerative diseases is presented, where the authors provide an overview on the ability of poly-phenols to modulate gut dysbiosis, oxidative stress, and inflammation against AD.Abstract:
Gut microbiota (GM) play a role in the metabolic health, gut eubiosis, nutrition, and physiology of humans. They are also involved in the regulation of inflammation, oxidative stress, immune responses, central and peripheral neurotransmission. Aging and unhealthy dietary patterns, along with oxidative and inflammatory responses due to gut dysbiosis, can lead to the pathogenesis of neurodegenerative diseases, especially Alzheimer's disease (AD). Although the exact mechanism between AD and GM dysbiosis is still unknown, recent studies claim that secretions from the gut can enhance hallmarks of AD by disturbing the intestinal permeability and blood-brain barrier via the microbiota-gut-brain axis. Dietary polyphenols are the secondary metabolites of plants that possess anti-oxidative and anti-inflammatory properties and can ameliorate gut dysbiosis by enhancing the abundance of beneficial bacteria. Thus, modulation of gut by polyphenols can prevent and treat AD and other neurodegenerative diseases. This review summarizes the role of oxidative stress, inflammation, and GM in AD. Further, it provides an overview on the ability of polyphenols to modulate gut dysbiosis, oxidative stress, and inflammation against AD.read more
Citations
More filters
Journal ArticleDOI
Effects of Natural Polyphenols on Oxidative Stress-Mediated Blood-Brain Barrier Dysfunction
TL;DR: This review summarized the sources of ROS production in multiple cells that constitute or surround the blood-brain barrier, such as BBB endothelial cells, astrocytes, microglia, and neutrophils, and summarized the effects of various natural polyphenols on BBB dysfunction to suggest a therapeutic strategy for BBB disruption-related brain diseases.
Journal ArticleDOI
Selenium Nanoparticles-Enriched Lactobacillus casei ATCC 393 Prevents Cognitive Dysfunction in Mice Through Modulating Microbiota-Gut-Brain Axis
TL;DR: In this article , the authors evaluated the effect of Lactobacillus casei ATCC 393 (L. casei-CA 393-SeNPs) against D-galactose/aluminum chloride-induced Alzheimer's disease (AD) in mice.
Journal ArticleDOI
Modulation of Gut Microbial Diversity through Non-Pharmaceutical Approaches to Treat Schizophrenia
TL;DR: It is proposed that non-pharmacotherapy using biotherapeutic products could be a potent treatment to improve cognitive impairment and other symptoms of schizophrenia and the need for comprehensive clinical assessment and follow-up of psychobiotic (pro and prebiotics) treatment in mental illness is endorsed.
Journal ArticleDOI
Effect of Fermentation on the Bioactive Compounds of the Black Soybean and Their Anti-Alzheimer’s Activity
TL;DR: In this article , the authors investigated the effect of fermented black soybeans with Pediococcus acidilactici (PA) bacteria against in vitro Alzheimer's disease (AD) biomarkers such as cholinesterase enzymes, inflammatory factors, oxidative stress, and presence of γ-aminobutyric acid (GABA) levels.
Journal ArticleDOI
Comprehensive profiling of bioactive compounds in germinated black soybeans via UHPLC-ESI-QTOF-MS/MS and their anti-Alzheimer’s activity
TL;DR: It is revealed that germination of black soybeans have promising potential to inhibit/prevent AD and can be used to develop functional foods.
References
More filters
Journal ArticleDOI
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
TL;DR: This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival, ROS homeostasis and antioxidant gene regulation, mitochondrial oxidative stress, apoptosis, and aging.
Journal ArticleDOI
Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects
Hua Zhang,Rong Tsao +1 more
TL;DR: A review on the chemistry and biochemistry of dietary polyphenols, their antioxidant and anti-inflammatory activities, and the underlying molecular mechanisms of their involvement in inflammation mediated metabolic diseases are also discussed in this article.
Journal ArticleDOI
Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly
Annamaria Cattaneo,Nadia Cattane,Samantha Galluzzi,Stefania Provasi,Nicola Lopizzo,Cristina Festari,Clarissa Ferrari,Ugo Paolo Guerra,Barbara Paghera,Cristina Muscio,Angelo Bianchetti,Giorgio Dalla Volta,Marinella Turla,Maria Cotelli,Michele Gennuso,Alessandro Prelle,Orazio Zanetti,Giulia Lussignoli,Dario Mirabile,Daniele Bellandi,Simona Gentile,Gloria Belotti,Daniele Villani,Taoufiq Harach,Tristan Bolmont,Alessandro Padovani,Marina Boccardi,Giovanni B. Frisoni +27 more
TL;DR: The data indicate that an increase in the abundance of a pro-inflammatory GMB taxon, Escherichia/Shigella, and a reduction in the abundances of an anti-inflammatoryTaxon, E. rectale, are possibly associated with a peripheral inflammatory state in patients with cognitive impairment and brain amyloidosis.
Journal ArticleDOI
Signaling by ROS drives inflammasome activation.
TL;DR: Findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP2/NalP3 inflammasome activation.
Journal ArticleDOI
History and progress of hypotheses and clinical trials for Alzheimer’s disease
TL;DR: It is proposed that fluoxetine, a selective serotonin reuptake inhibitor, has the potential to treat AD and the combination of hypometabolism and autophagy deficiency is likely to be a causative factor for AD.