The proliferation of astrocytes around a needle wound in the rat brain.

Home
/
Papers
/
The proliferation of astrocytes around a needle wound in the rat brain.

Journal Article•

The proliferation of astrocytes around a needle wound in the rat brain.

01 May 1970-Journal of Anatomy (Wiley-Blackwell)-Vol. 106, pp 471-487

About: This article is published in Journal of Anatomy.The article was published on 1970-05-01 and is currently open access. It has received 256 citations till now. The article focuses on the topics: Neuroglia.

...read moreread less

Citations

PDF

Open Access

More filters

Journal Article•DOI•

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

[...]

Fiona Doetsch¹, Isabelle Caillé¹, Daniel A. Lim¹, José Manuel García-Verdugo², Arturo Alvarez-Buylla¹ - Show less +1 more•Institutions (2)

Rockefeller University¹, University of Valencia²

11 Jun 1999-Cell

TL;DR: It is shown that SVZ astrocytes act as neural stem cells in both the normal and regenerating brain and give rise to cells that grow into multipotent neurospheres in vitro.

...read moreread less

3,890 citations

Journal Article•DOI•

The glial scar and central nervous system repair

[...]

James W. Fawcett¹, Richard A. Asher¹•Institutions (1)

University of Cambridge¹

01 Aug 1999-Brain Research Bulletin

TL;DR: Deyelinated plaques in multiple sclerosis consists mostly of scar-type astrocytes and naked axons, but astroCytes inhibit the migration of both oligodendrocyte precursors and Schwann cells which must restrict their access to demyelinated axons.

...read moreread less

1,833 citations

Journal Article•DOI•

Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays

[...]

Roy Biran¹, David C. Martin², Patrick A. Tresco¹•Institutions (2)

University of Utah¹, University of Michigan²

01 Sep 2005-Experimental Neurology

TL;DR: Persistent ED1 up-regulation and neuronal loss was not observed in microelectrode stab controls indicating that the phenotype did not result from the initial mechanical trauma of electrode implantation, but was associated with the foreign body response.

...read moreread less

834 citations

Cites background from "The proliferation of astrocytes aro..."

...The fact that astrocytes swell and divide after penetrating CNS trauma (Cavanagh, 1970; Mathewson and Berry, 1985) coupled with the finding that the areas of astrogliosis hinder diffusion in the brain (Roitbak and Sykova, 1999) supports a model for astrocyte-mediated erosion of recording capability with this class of devices....
[...]

Journal Article•DOI•

CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.

[...]

Malgorzata Zawadzka¹, Malgorzata Zawadzka², Leanne E. Rivers³, Stephen P.J. Fancy⁴, Stephen P.J. Fancy², Chao Zhao², Richa B. Tripathi³, Françoise Jamen³, Kaylene M. Young³, Alexander Goncharevich², Hartmut B.F. Pohl⁵, Matteo Rizzi³, David H. Rowitch⁴, Nicoletta Kessaris³, Ueli Suter⁵, William D. Richardson³, Robin J.M. Franklin² - Show less +13 more•Institutions (5)

Nencki Institute of Experimental Biology¹, University of Cambridge², University College London³, University of California, San Francisco⁴, ETH Zurich⁵

04 Jun 2010-Cell Stem Cell

TL;DR: This work has used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions.

...read moreread less

563 citations

Cites background from "The proliferation of astrocytes aro..."

...However, given that parenchymal astrocytes can divide in response to injury, it seems probable that many of the newly generated astrocytes (identified by expression of AQP4) are derived from local, proliferating astrocytes rather than from cells in the EZ, at a distance from the lesion (Buffo et al., 2008; Cavanagh, 1970; Chen et al., 2008)....
[...]

Journal Article•DOI•

Quantitative aspects of reactive gliosis: A review

[...]

William T. Norton¹, Dennis A. Aquino¹, Isao Hozumi¹, Fung-Chow Chiu¹, Celia F. Brosnan¹ - Show less +1 more•Institutions (1)

Albert Einstein College of Medicine¹

01 Sep 1992-Neurochemical Research

TL;DR: There are different biological mechanisms for induction and maintenance of reactive gliosis, which, depending on the kind of tissue damage, result in different expressions of the gliotic response.

...read moreread less

Abstract: Recent studies of gliosis in a variety of animal models are reviewed. The models include brain injury, neurotoxic damage, genetic diseases and inflammatory demyelination. These studies show that reactive gliosis is not a stereotypic response, but varies widely in duration, degree of hyperplasia, and time course of expression of GFAP immunostaining, content and mRNA. We conclude that there are different biological mechanisms for induction and maintenance of reactive gliosis, which, depending on the kind of tissue damage, result in different expressions of the gliotic response.

...read moreread less

545 citations