The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly.
Shoujun Chen,David E. Birk +1 more
Reads0
Chats0
TLDR
Small leucine‐rich proteoglycans regulate assembly of the extracellular matrix, which defines the microenvironment, modulating both the extracllular matrix and cellular functions, with an impact on tissue function.Abstract:
Small leucine-rich proteoglycans (SLRPs) are involved in a variety of biological and pathological processes. This review focuses on their regulatory roles in matrix assembly. SLRPs have protein cores and hypervariable glycosylation with multivalent binding abilities. During development, differential interactions of SLRPs with other molecules result in tissue-specific spatial and temporal distributions. The changing expression patterns play a critical role in the regulation of tissue-specific matrix assembly and therefore tissue function. SLRPs play significant structural roles within extracellular matrices. In addition, they play regulatory roles in collagen fibril growth, fibril organization and extracellular matrix assembly. Moreover, they are involved in mediating cell-matrix interactions. Abnormal SLRP expression and/or structures result in dysfunctional extracellular matrices and pathophysiology. Altered expression of SLRPs has been found in many disease models, and structural deficiency also causes altered matrix assembly. SLRPs regulate assembly of the extracellular matrix, which defines the microenvironment, modulating both the extracellular matrix and cellular functions, with an impact on tissue function.read more
Citations
More filters
Journal ArticleDOI
Extracellular matrix structure.
TL;DR: The complex ECM structure is emphasized as to provide a better understanding of its dynamic structural and functional multipotency and the implication of the various families of ECM macromolecules in health and disease is presented.
Journal ArticleDOI
Extracellular matrix assembly: a multiscale deconstruction
TL;DR: The product is a specific ECM signature that is comprised of unique compositional and topographical features that both reflect and facilitate the functional requirements of the tissue.
Journal ArticleDOI
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
Renato V. Iozzo,Liliana Schaefer +1 more
TL;DR: The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants and is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores.
Journal ArticleDOI
Corneal structure and transparency
Keith M. Meek,Carlo Knupp +1 more
TL;DR: The current state of knowledge about the three-dimensional stromal architecture at the microscopic level is described, and about the control mechanisms at the nanoscopic level that lead to optical transparency are described.
Journal ArticleDOI
Myocardial Extracellular Matrix An Ever-Changing and Diverse Entity
TL;DR: This review will discuss the fundamental role of the matrix in cardiac development, homeostasis, and remodeling, from a glycobiology point of view, and the role of glycosylation in altering the ultimate function of glycoproteins, proteoglycans, and glycosaminogly cans in the myocardium.
References
More filters
Journal ArticleDOI
Collagen fibril formation
TL;DR: Preliminary evidence from invertebrates is included which suggests that the principles for bipolar fibril assembly were established at least 500 million years ago, and how mature fibrils are assembled from early fibrILS is reviewed.
Journal ArticleDOI
Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility
Keith G. Danielson,Helene Baribault,David F. Holmes,Helen K. Graham,Karl E. Kadler,Renato V. Iozzo +5 more
TL;DR: A fundamental role is demonstrated for decorin in regulating collagen fiber formation in vivo in mice harboring a targeted disruption of the decorin gene, which provides an explanation for the reduced tensile strength of the skin.
Journal ArticleDOI
Evidence for a prostate cancer susceptibility locus on the X chromosome.
Jianfeng Xu,Deborah A. Meyers,Diha Freije,Sarah D. Isaacs,Kathy E. Wiley,Deborah Nusskern,Charles M. Ewing,Eric P. Wilkens,Piroska Bujnovszky,G. Steven Bova,Patrick C. Walsh,William B. Isaacs,Johanna Schleutker,Mika P. Matikainen,Teuvo L.J. Tammela,Tapio Visakorpi,Olli Kallioniemi,Rebecca Berry,Daniel J. Schaid,Amy J. French,Shannon K. McDonnell,Jennifer J. Schroeder,Michael L. Blute,Stephen N. Thibodeau,Henrik Grönberg,Monika Emanuelsson,Jan-Erik Damber,Anders Bergh,Björn Anders Jonsson,Jeffrey R. Smith,Joan E. Bailey-Wilson,John D. Carpten,Dietrich A. Stephan,Elizabeth M. Gillanders,Isaac Amundson,Tommi Kainu,Diana Freas-Lutz,Agnes Baffoe-Bonnie,Anne Van Aucken,Raman Sood,Francis S. Collins,Michael J. Brownstein,Jeffrey M. Trent +42 more
TL;DR: Evidence for genetic locus heterogeneity was observed and genetic mapping of the locus represents an important initial step in the identification of an X-linked gene implicated in the aetiology of HPC.
Journal ArticleDOI
Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators.
TL;DR: A working hypothesis is put forward for how fibronectin and integrins determine the site of fibril assembly, and collagens V and XI (the nucleators) initiate collagen fibrillogenesis.
Journal ArticleDOI
Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
T. Xu,Paolo Bianco,Paolo Bianco,Larry W. Fisher,Glenn Longenecker,Erica Smith,Steven A. Goldstein,Jeffrey Bonadio,Adele L. Boskey,Anne-Marie Heegaard,Beatrice Sommer,Kazuhito Satomura,Pedro Domínguez,Chengyan Zhao,Ashok B. Kulkarni,Pamela Gehron Robey,Marian F. Young +16 more
TL;DR: This is the first report in which deficiency of a non-collagenous ECM protein leads to a skeletal phenotype that is marked by low bone mass that becomes more obvious with age and may serve as an animal model to study the role of ECM proteins in osteoporosis.
Related Papers (5)
The role of small leucine-rich proteoglycans in collagen fibrillogenesis
Sebastian Kalamajski,Åke Oldberg +1 more
Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction.
Liliana Schaefer,Renato V. Iozzo +1 more
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
Renato V. Iozzo,Liliana Schaefer +1 more