The retinoblastoma protein and cell cycle control
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Cites background from "The retinoblastoma protein and cell..."
...Conversely, constitutive activation of the D cyclin pathway can reduce or overcome certain mitogen requirements for cell proliferation and thereby contribute to oncogenic transformation (for reviews, see Weinberg 1995; Sherr 1996; Bartkova et al. 1997)....
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...…cyclin E–CDK2 becomes active and completes this process by phosphorylating Rb on additional sites (Matsushime et al. 1994; Meyerson and Harlow 1994; Mittnacht et al. 1994; Kitagawa et al. 1996; Ezhevsky et al. 1997; Lundberg and Weinberg 1998; for review, see Weinberg 1995; Sherr 1996; Taya 1997)....
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5,509 citations
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Cites background from "The retinoblastoma protein and cell..."
...…mutations that constitutively activate Ras proteins tumor suppressor protein, Rb, allowing progression ofare frequent in human cancers (reviewed by Bos, 1988). the cell-cycle toward S phase (reviewed by Sherr andOncogenic ras efficiently transforms most immortal roRoberts, 1995; Weinberg, 1995)....
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References
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"The retinoblastoma protein and cell..." refers background in this paper
...Radiation and other DNA-damaging agents also block pRB phosphorylation through use of another CDKI, termed variously p21, Wafl, and Cipl (EI-Deiry et al., 1993; Harper et al., 1993; Dulic et al., 1994)....
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5,726 citations
"The retinoblastoma protein and cell..." refers background in this paper
...Radiation and other DNA-damaging agents also block pRB phosphorylation through use of another CDKI, termed variously p21, Wafl, and Cipl (EI-Deiry et al., 1993; Harper et al., 1993; Dulic et al., 1994)....
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5,562 citations
"The retinoblastoma protein and cell..." refers background in this paper
...While initially discovered as a phenomenon of cells grown in culture (Hayflick, 1965), it appears increasingly likely that senescence represents an antineoplastic mechanism designed to limit the proliferative potential of cell clones in the body....
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"The retinoblastoma protein and cell..." refers background in this paper
...Normally a highly unstable protein with a lifetime of 15 min or so, its steadystate levels increase rapidly upon DNA damage, p53 in turn activates expression of the p21 CDKI, and p21 then blocks the activity of both CDK2 and CDK4/CDK6 (Kastan et al., 1991 ; Hall et al., 1993)....
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