The role and regulation of blebs in cell migration
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1,128 citations
662 citations
Cites background from "The role and regulation of blebs in..."
...Several studies report, for example, that amoeboid migration is often based on a contractile cell rear inducing a retrograde flow in the cell cortex (Heuzé et al., 2013; Paluch and Raz, 2013; Poincloux et al., 2011)....
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...The velocity of amoeboid migration is often higher than that of mesenchymal migration (Panková et al., 2010) and it appears to involve a range of different sub-modes, such as bleb-based migration or gliding (Paluch and Raz, 2013)....
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..., 2010) and it appears to involve a range of different sub-modes, such as bleb-based migration or gliding (Paluch and Raz, 2013)....
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...Several studies report, for example, that amoeboid migration is often based on a contractile cell rear inducing a retrograde flow in the cell cortex (Heuzé et al., 2013; Paluch and Raz, 2013; Poincloux et al., 2011)....
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619 citations
Cites background from "The role and regulation of blebs in..."
...com components and surrounding cells [5,6]....
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...By contrast, in situations of low adhesion or if cells lack integrins, cells tend to migrate using bleb-based motility [5]....
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493 citations
487 citations
References
1,288 citations
"The role and regulation of blebs in..." refers background in this paper
...Indeed, leukocytes devoid of receptors that would support adhesion to the extracellular environment were shown to migrate by squeezing and exerting pushing forces perpendicular to the cell boundary [55 ,56]....
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1,239 citations
"The role and regulation of blebs in..." refers background in this paper
...Control of bleb formation Whereas some cell types appear to generate exclusively either actin polymerization-based protrusions or blebs driven by actomyosin contractility [5 ,6], other cells are capable of switching the mode of protrusion formation in response to properties of the environment and intracellular signaling [27 ,28 ,46,47]....
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...The ability to switch between protrusion types and motility modes has been proposed to facilitate cancer dissemination; switching could indeed allow cells that migrate through complex and changing environments to select the most efficient migration mode for a given environment (reviewed in [8,46,48])....
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924 citations
899 citations
"The role and regulation of blebs in..." refers background in this paper
...In the same direction, as shown in various cell types, weakening the tethering between the membrane and the cell cortex facilitates bleb formation [10 ,13,18 ,25]....
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894 citations
"The role and regulation of blebs in..." refers background in this paper
...Blebs can thus form as an alternative to, or in combination with lamellipodia (Figure 1), and are a key protrusion type in 3D migration [11]....
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