Journal ArticleDOI
The role of brain dopamine in behavioral regulation and the actions of psychotropic drugs.
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TLDR
It is shown that locomotor hyperactivity, an animal model for the central stimulant effects of amphetamine, is mediated by brain norepinephrine, and hyperactivity of dopamine systems in the brain may be a factor in the pathophysiology of this condition.Abstract:
By comparing biochemical and behavioral actions of d- and l- isomers of amphetamine, the authors show that locomotor hyperactivity, an animal model for the central stimulant effects of amphetamine, is mediated by brain norepinephrine. By contrast, stereotyped, compulsive gnawing behavior in rats, which resembles symptoms of amphetamine psychosis, appears to be regulated by brain dopamine. Since haloperidol, a potent blocker of dopamine receptors, is uniquely efficacious in treating Gilles de la Tourette's disease, the authors suggest that hyperactivity of dopamine systems in the brain may be a factor in the pathophysiology of this condition.read more
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Journal ArticleDOI
The Physiology, Signaling, and Pharmacology of Dopamine Receptors
TL;DR: D dopamine receptor classification, their basic structural and genetic organization, their distribution and functions in the brain and the periphery, and their regulation and signal transduction mechanisms are discussed.
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Sensation seeking: A comparative approach to a human trait
TL;DR: A model is suggested that relates mood, behavioral activity, sociability, and clinical states to activity of the central catecholamine neurotransmitters and to neuroregulators and other transmitters that act in opposite ways on behavior or stabilize activity in the arousal systems.
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Catecholamines in the brain as mediators of amphetamine psychosis.
TL;DR: Findings provoke the speculation that specific and distinct effects of amphetamines on dopamine and norepinephrine neurons may combine to account for major symptoms of amphetamine psychosis.
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Amphetamine psychosis: Behavioral and biochemical aspects
TL;DR: This chapter discusses the behavioral and biochemical aspects of amphetamine psychosis, which was characterized by a brisk emotional reaction, usually in the direction of anxiety.
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Norepinephrine and dopamine in the limbic system of the rat.
TL;DR: Norepinephrine and dopamine, which were assayed by means of a sensitive enzymatic isotopic method, were found to be unevenly distributed among the areas which make up the limbic system.