The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
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429 citations
Cites background from "The Role of Genes, Stress, and Dopa..."
...Albeit the neurobiology of SZ remains to be elucidated, many hypotheses have been proposed to clarify the disease, including the neurodevelopmental hypothesis, the glutamate hypothesis, and the most accepted, dopamine hypothesis (Kambeitz et al. 2014; Hu et al. 2015; Schmidt and Mirnics 2015; Howes et al. 2017; Wang et al. 2017)....
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Cites methods from "The Role of Genes, Stress, and Dopa..."
...For the meta-analysis of presynaptic dopamine function in schizophrenia the inclusion criteria were: (1) studies of patients with schizophrenia diagnosed in accordance with criteria specified in the Diagnostic and Statistical Manual for Mental Disorders (DSM), or the International Classification of Diseases (ICD)24,25 and a control group; (2) reporting molecular imaging measures of presynaptic dopaminergic function (see supplementary methods for further details) for both the patient and control groups; (3) providing data enabling the estimation of mean difference between control and clinical groups for the dopaminergic measure; and (4) For the subdivision analysis only studies reporting all 3 subdivisions (limbic, associative, and sensorimotor subdivisions) were included to enable comparisons across regions....
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159 citations
Cites background from "The Role of Genes, Stress, and Dopa..."
...Risk factors HVHs consistently report the presence ofwell-established latent risk factors for psychosis, i.e. genetic loading (Howes et al., 2016) and childhood trauma (Varese et al., 2012)....
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...genetic loading (Howes et al., 2016) and childhood trauma (Varese et al....
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References
6,809 citations
"The Role of Genes, Stress, and Dopa..." refers background in this paper
...Akt3 was associated with schizophrenia in the GWAS described above (70), while Akt1 has been linked to schizophrenia in other studies (73,74)....
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...Among the 108 loci associated with schizophrenia in the largest scale genomewide association study (GWAS) to date, one was for the D2 receptor (70)....
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4,847 citations
"The Role of Genes, Stress, and Dopa..." refers background in this paper
...Furthermore, a recent systematic pathway analysis of the Psychiatric Genomics Consortium’s enlarged sample (PGC2) GWAS findings identified the top pathway for genes associated with schizophrenia as being that for dopaminergic synapse (71) (Holmans P, Ph....
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3,842 citations
2,755 citations
2,320 citations
"The Role of Genes, Stress, and Dopa..." refers background in this paper
...Stress-induced catecholamine release can impair working memory (90)....
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