The role of Hypoxia-Inducible Factor-1alpha and its signaling in melanoma.
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TLDR
The role of HIF-1α in oncogenic processes includes angiogenesis, tumor metabolism, cell proliferation, and metastasis, which has been examined in various malignancies, such as melanoma.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2021-07-02 and is currently open access. It has received 25 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & Wnt signaling pathway.read more
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Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway.
N. C. Sondermann,S. Fassbender,Frederick Hartung,Anna M. Hätälä,Katharina Rolfes,Christoph F.A. Vogel,Thomas Haarmann-Stemmann +6 more
TL;DR: In this article , the authors provide an overview about some of the most important non-canonical functions of AHR, including crosstalk with major signaling pathways involved in controlling cell fate and function, immune responses, adaptation to low oxygen levels and oxidative stress, ubiquitination and proteasomal degradation.
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Current understanding of epigenetics role in melanoma treatment and resistance
TL;DR: In this paper , the authors conducted a review to discuss the melanoma risk factors and represent the current knowledge about the factors related to its etiopathogenesis, and various epigenetic pathways which are involved in melanoma progression, treatment, and chemo-resistance, as well as employed epigenetic factors as a solution to the problems.
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Mechanisms of resistance to immune checkpoint inhibitors in melanoma: What we have to overcome?
Dimitrios C. Ziogas,Charalampos Theocharopoulos,Tilemachos Koutouratsas,John B. A. G. Haanen,Helen Gogas +4 more
TL;DR: In this paper , the authors discuss how these parameters compromise the efficacy of ICIs, with an emphasis on the lessons learned by the latest melanoma studies; and in parallel, they describe the main ongoing approaches to overcome the resistance to immunotherapy.
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Active Tumor-Targeting Nano-formulations Containing Simvastatin and Doxorubicin Inhibit Melanoma Growth and Angiogenesis
Giorgiana Negrea,Valentin Rauca,Márta Mészáros,Laura Patras,Lavinia Lupuţ,Emilia Licarete,Vlad Al. Toma,Alina Porfire,Danina Muntean,Alina Sesarman,Manuela Banciu +10 more
TL;DR: In this paper , a combination therapy consisting of sequential administration of simvastatin incorporated in IL-13-functionalized long-circulating liposomes and doxorubicin encapsulated into PEG-coated extracellular vesicles (PEG-EV-DOX) was proposed to selectively target both tumorassociated macrophages and melanoma cells.
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Oxidative Stress and Immune Response in Melanoma: Ion Channels as Targets of Therapy
TL;DR: In this article , the effects of oxidative stress on ion channels on a molecular and cellular level and in the context of melanoma progression and immune evasion was discussed, and the possible role of ion channels as targets of alternative therapeutic strategies in melanoma was discussed.
References
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Journal ArticleDOI
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.
TL;DR: It is shown that vascular endothelial growth factor (VEGF) probably functions as a hypoxia-inducible angiogenic factor and is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci and the clustering of capillaries alongside VEGF-producing cells.
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STATs and Gene Regulation
TL;DR: The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins.
Journal ArticleDOI
Roles of the raf/mek/erk pathway in cell growth, malignant transformation and drug resistance
James A. McCubrey,Linda S. Steelman,William H. Chappell,Stephen L. Abrams,Ellis W.T. Wong,Fumin Chang,Brian D. Lehmann,David M. Terrian,Michele Milella,Agostino Tafuri,Franca Stivala,Massimo Libra,Jörg Bäsecke,Camilla Evangelisti,Alberto M. Martelli,Richard A. Franklin +15 more
TL;DR: The Raf/MEK/ERK pathway has different effects on growth, prevention of apoptosis, cell cycle arrest and induction of drug resistance in cells of various lineages which may be due to the presence of functional p53 and PTEN and the expression of lineage specific factors.
Journal ArticleDOI
PI3K/Akt signalling pathway and cancer ☆
Juan Ángel Fresno Vara,Enrique Casado,Javier de Castro,Paloma Cejas,Cristobal Belda-Iniesta,Manuel González-Barón +5 more
TL;DR: The PI3K/Akt pathway is involved in many of the mechanisms targeted by these new drugs, thus a better understanding of this crossroad can help to fully exploit the potential benefits of these new agents.
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Hypoxia signalling in cancer and approaches to enforce tumour regression
TL;DR: There are new approaches to enforce necrotic cell death and tumour regression by targeting tumour metabolism and pHi-control systems.