The role of iodine in human growth and development.
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Cites background from "The role of iodine in human growth ..."
...Thyroid hormones play an important role in neurodevelopment and numerous neurological processes including neuronal cell differentiation, maturation and migration, myelination, neurotransmission, and synaptic plasticity (Zimmermann, 2009, 2011; Melse-Boonstra and Jaiswal, 2010)....
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...Nutrients provide building blocks that play a critical role in cell proliferation, DNA synthesis, neurotransmitter and hormone metabolism, and are important constituents of enzyme systems in the brain (Bhatnagar and Taneja, 2001; Lozoff and Georgieff, 2006; Zeisel, 2009; De Souza et al., 2011; Zimmermann, 2011)....
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...The association between mild-moderate maternal iodine deficiency and cognitive development is not as clear as it is when iodine deficiency is severe (Forrest, 2004; Zimmermann, 2007, 2009, 2011; Melse-Boonstra and Jaiswal, 2010)....
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...…degree of cognitive impairment (when compared to children from iodine sufficient areas), and iodine supplementation trials in school age children have provided some promising results with respect to improvement of some cognitive processes (Zimmermann, 2007, 2011; MelseBoonstra and Jaiswal, 2010)....
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...…building blocks that play a critical role in cell proliferation, DNA synthesis, neurotransmitter and hormone metabolism, and are important constituents of enzyme systems in the brain (Bhatnagar and Taneja, 2001; Lozoff and Georgieff, 2006; Zeisel, 2009; De Souza et al., 2011; Zimmermann, 2011)....
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308 citations
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Cites background from "The role of iodine in human growth ..."
...Disruptions in thyroid signalling can have widespread effects on infant development (Zimmermann, 2011)....
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109 citations
Cites background from "The role of iodine in human growth ..."
...Moderate-to-severe iodine deficiency during pregnancy also increases rates of spontaneous abortion, reduces birth weight, and increases infant mortality [84]....
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References
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"The role of iodine in human growth ..." refers background in this paper
...Approximately 95% of irculating IGF-1 is bound to insulin-like growth factor binding rotein (IGFBP)-3; binding prolongs the half-life of circulating GF-1 and may target IGF-I towards growth stimulation and way from glucose metabolism [94,96]....
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...Insulin-like growth factor (IGF)-1 is a growth factor that medites many of the effects of GH [94,95]....
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2,197 citations
"The role of iodine in human growth ..." refers background in this paper
...However, maternal hyroid dysfunction in these studies was presumably not due to D, as they were done in the USA [39] and in the Netherlands 40]....
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...[39], he IQ scores of 7–9-year-old children of mothers with subclinial hypothyroidism during pregnancy (an increased TSH in the 2nd rimester) were 4 points lower compared to children from mothrs with normal thyroid function during pregnancy....
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