The role of lipids in the epidermal barrier to water diffusion.
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Results obtained with human abdominal autopsy skin were similar in that dimethylsulfoxide removed a minimal amount of lipid, but markedly increased the diffusion rate of tritiated water.About:
This article is published in Journal of Investigative Dermatology.The article was published on 1970-08-01 and is currently open access. It has received 97 citations till now. The article focuses on the topics: Tritiated water.read more
Citations
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Barrier Function of the Skin: “La Raison d'Être” of the Epidermis
TL;DR: More sophisticated understanding of epidermal barrier function will lead to more rational therapy of a host of skin conditions in which the barrier is impaired, current work has focused on developing a more physiologic mix of lipids for topical application to skin.
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Presence of intact intercellular lipid lamellae in the upper layers of the stratum corneum
TL;DR: Stacking of lamellae filling the intercellular spaces in the uppermost layers of the stratum corneum is demonstrated and suggests that the lipid bilayer adjacent to the corneocyte cell envelope may be assembled from lipids not derived from MCGs.
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Percutaneous Transport in Relation to Stratum Corneum Structure and Lipid Composition
Peter M. Elias,Peter M. Elias,Eugene R. Cooper,Eugene R. Cooper,Antoinette Korc,Antoinette Korc,Barbara E. Brown,Barbara E. Brown +7 more
TL;DR: Differences in the thickness and the number of cell layers in the stratum corneum are insufficient to account for differences in percutaneous transport across leg and abdomen, and total lipid concentration may be the critical factor governing skin permeability.
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Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations
TL;DR: Data obtained from infrared, thermal, and fluorescence spectroscopic examinations of theSC and its components imply enhancer improved permeation of solutes through the SC is associated with alterations involving the hydrocarbon chains of the SC lipid components.
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Lipids and the epidermal permeability barrier
Peter M. Elias,Peter M. Elias +1 more
References
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Journal ArticleDOI
Factors Which Influence the Water Content of the Stratum Corneum
TL;DR: It is apparent that the water content of the cornified epithelium is a more important factor in maintaining the flexibility of this layer than is its oil content.
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Mechanism of Percutaneous Absorption: III. The Effect of Temperature on the Transport of Non-Electrolytes Across the Skin*
TL;DR: A reconciliation of these contrary theories and a re-interpretation of the conflicting data is really long overdue and quite necessary if a useful link between studies of skin permeability in the laboratory and their relevance to the topical application of a drug by the physician is to be obtained.
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Variability in the chemical composition of human skin surface lipids.
TL;DR: Quantitative thin-layer chromatography was employed for the analysis of forehead surface lipid from adult males over periods of up to fourteen months, and for each subject the lipid composition remained relatively constant.
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The Water Barrier in Human Epidermis: Physical and Chemical Nature
Henry D. Onken,Carl A. Moyer +1 more
TL;DR: A theoretical scheme of the physical-chemical nature of the water vapor barrier, based on observations, and on previous data, is presented, indicating that the physical structural characteristics of the epidermis have little to do with maintenance of theWater vapor barrier.