The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases.
Jae-Won Lee,Wanjoo Chun,Hee Jae Lee,Jae-Hong Min,Jae-Hong Min,Seong-Man Kim,Seong-Man Kim,Ji-Yun Seo,Ji-Yun Seo,Kyung-Seop Ahn,Sei-Ryang Oh +10 more
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TLDR
In this article, a review summarizes the functions of macrophages and their associated underlying mechanisms in the development of acute lung injury (ALI), acute respiratory distress syndrome (ARDS), ARDS related to COVID-19 (coronavirus disease 2019), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)), allergic asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF).Abstract:
Macrophages play an important role in the innate and adaptive immune responses of organ systems, including the lungs, to particles and pathogens. Cumulative results show that macrophages contribute to the development and progression of acute or chronic inflammatory responses through the secretion of inflammatory cytokines/chemokines and the activation of transcription factors in the pathogenesis of inflammatory lung diseases, such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), ARDS related to COVID-19 (coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)), allergic asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). This review summarizes the functions of macrophages and their associated underlying mechanisms in the development of ALI, ARDS, COVID-19-related ARDS, allergic asthma, COPD, and IPF and briefly introduces the acute and chronic experimental animal models. Thus, this review suggests an effective therapeutic approach that focuses on the regulation of macrophage function in the context of inflammatory lung diseases.read more
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Oxidative Stress, Kinase Activation, and Inflammatory Pathways Involved in Effects on Smooth Muscle Cells During Pulmonary Artery Hypertension Under Hypobaric Hypoxia Exposure.
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Pulmonary macrophages and their different roles in health and disease.
TL;DR: In this article, the authors discuss the origin and function of pulmonary macrophages in the context of homeostasis, infectious and non-infectious lung diseases, and discuss the role of macrophage in lung damage during persistent inflammation or continuous exposure to antigens.
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Lagerstroemia ovalifolia Exerts Anti- Inflammatory Effects in Mice of LPSInduced ALI via Downregulating of MAPK and NF-κB Activation.
Jae-Hong Min,Seong-Man Kim,Ji-Won Park,Nam Hoon Kwon,Soo Hyeon Goo,Ngatinem,Sri Ningsih,Jin-Hyub Paik,Sangho Choi,Sei-Ryang Oh,Sang-Bae Han,Kyung-Seop Ahn,Jae-Won Lee +12 more
TL;DR: In this article, a mouse model of LPS-induced acute lung injury (ALI) was used to evaluate the anti-inflammatory effects of Lagerstroemia ovalifolia Teijsm. & Binn.
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