Journal ArticleDOI
The role of metabolism in the pathogenesis of osteoarthritis
Ali Mobasheri,Ali Mobasheri,Margaret P. Rayman,Oreste Gualillo,Jérémie Sellam,Peter M. van der Kraan,Ursula Fearon +6 more
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TLDR
The current state of knowledge on the role of impaired metabolism in the cells of the osteoarthritic joint is summarized, and areas for future research are highlighted, such as the potential to target metabolic pathways and mediators therapeutically.Abstract:
Metabolism is important for cartilage and synovial joint function. Under adverse microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a resting regulatory state to a highly metabolically activate state to maintain energy homeostasis. This phenomenon also leads to an increase in metabolic intermediates for the biosynthesis of inflammatory and degradative proteins, which in turn activate key transcription factors and inflammatory signalling pathways involved in catabolic processes, and the persistent perpetuation of drivers of pathogenesis. In the past few years, several studies have demonstrated that metabolism has a key role in inflammatory joint diseases. In particular, metabolism is drastically altered in osteoarthritis (OA) and aberrant immunometabolism may be a key feature of many phenotypes of OA. This Review focuses on aberrant metabolism in the pathogenesis of OA, summarizing the current state of knowledge on the role of impaired metabolism in the cells of the osteoarthritic joint. We also highlight areas for future research, such as the potential to target metabolic pathways and mediators therapeutically.read more
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Desktop-stereolithography 3D printing of a radially oriented extracellular matrix/mesenchymal stem cell exosome bioink for osteochondral defect regeneration.
Pengfei Chen,Lin Zheng,Lin Zheng,Yiyun Wang,Min Tao,Ziang Xie,Chen Xia,Chenhui Gu,Jiaxin Chen,Pengcheng Qiu,Sheng Mei,Lei Ning,Yiling Shi,Chen Fang,Shunwu Fan,Xianfeng Lin +15 more
TL;DR: It is demonstrated that the 3D printed, radially oriented ECM/GelMA/exosome scaffold could be a promising strategy for early OA treatment.
Journal ArticleDOI
Chondrocyte dedifferentiation and osteoarthritis (OA)
Edith Charlier,Céline Deroyer,Federica Ciregia,Olivier Malaise,Sophie Neuville,Zelda Plener,Michel Malaise,Dominique de Seny +7 more
TL;DR: Molecular knowledge underlying dedifferentiation process is presented, connections between dedifferentiated-like and OA are emphasized and therapeutic strategies aiming at the maintenance of chondrogenic phenotype are considered.
Journal ArticleDOI
The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review.
TL;DR: The role of PI3K/AKT/mTOR signaling in cartilage degradation, subchondral bone dysfunction, and synovial inflammation is highlighted, and how this signaling pathway affects development of the disease is discussed.
Journal ArticleDOI
Type H blood vessels in bone modeling and remodeling.
TL;DR: In this paper, a review summarizes the current understanding of signaling pathways that regulate type H vessels and how typeH vessels modulate osteogenesis, and discusses considerations for therapeutic approaches targeting type H vessel to promote fracture healing, prevent pathological bone loss, osteonecrosis, osteoarthritis, and bone metastases.
Journal ArticleDOI
Metabolic regulation of inflammation
TL;DR: The metabolic challenges faced byimmune cells in states of homeostasis and inflammation are outlined, as well as the variety of metabolic configurations utilized by immune cells during differentiation and activation.
References
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Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
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A guide to immunometabolism for immunologists
TL;DR: A brief refresher course on six of the major metabolic pathways involved in immunometabolism is provided, giving specific examples of how precise changes in the metabolites of these pathways shape the immune cell response.
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The cellular and signaling networks linking the immune system and metabolism in disease
Olivia Osborn,Jerrold M. Olefsky +1 more
TL;DR: This work discusses how various networks underlie the etiology of the inflammatory component of insulin resistance, with a particular focus on the central roles of macrophages in adipose tissue and liver.
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Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis
TL;DR: Low-grade inflammation induced by the metabolic syndrome, innate immunity and inflammaging are some of the more recent arguments in favor of the inflammatory theory of OA and highlighted in this review.
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The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
Jérémie Sellam,Francis Berenbaum +1 more
TL;DR: As synovitis is associated with clinical symptoms and also reflects joint degradation in OA, synovium-targeted therapy could help alleviate the symptoms of the disease and perhaps also prevent structural progression.