The role of metastasis-directed therapy and local therapy of the primary tumor in the management of oligometastatic prostate cancer.
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TLDR
Review of the available studies suggests that stereotactic radiotherapy of metastatic lesions in oligorecurrent disease is a feasible and safe modality for managing oligometastatic prostate cancer.Abstract:
Oligometastasis has been proposed as an intermediate stage of cancer spread between localized disease and widespread metastasis. Oligometastatic malignancy is now being diagnosed more frequently as the result of improvements in diagnostic modalities such as functional imaging. The importance of oligometastasis in managing metastatic prostate cancer is that it is possible to treat with a curative aim by metastasis-directed or local therapy in selected patients. Many studies have shown that these aggressive treatments lead to improved survival in other oligometastatic malignancies. However, few studies have shown definitive benefits of metastasis-directed or local therapy in oligometastatic prostate cancer. Review of the available studies suggests that stereotactic radiotherapy (RT) of metastatic lesions in oligorecurrent disease is a feasible and safe modality for managing oligometastatic prostate cancer. Also, stereotactic RT can delay the start of androgen deprivation therapy. Many retrospective studies of metastatic prostate cancer have shown that patients undergoing local therapy seem to have superior overall and cancer-specific survival compared with patients not receiving local therapy. Ongoing prospective randomized trials would be helpful to evaluate the role of local therapy in oligometastatic prostate cancer.read more
Citations
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Sec23a mediates miR-200c augmented oligometastatic to polymetastatic progression
Zhiwei Sun,Shixia Zhou,Junling Tang,Ting Ye,Jingyuan Li,Doudou Liu,Jian Zhou,Jianyu Wang,H. Rosie Xing +8 more
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Treatment of Oligometastatic Hormone-Sensitive Prostate Cancer: A Comprehensive Review.
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CUL4B regulates cancer stem-like traits of prostate cancer cells by targeting BMI1 via miR200b/c.
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References
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EAU Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent—Update 2013
Axel Heidenreich,Patrick J. Bastian,Joaquim Bellmunt,Michel Bolla,Steven Joniau,Theodor van der Kwast,Malcolm David Mason,Vsevolod Matveev,Thomas Wiegel,Filiberto Zattoni,Nicolas Mottet +10 more
TL;DR: Current evidence is insufficient to warrant widespread population-based screening by prostate-specific antigen (PSA) for PCa, and watchful waiting is a treatment alternative to androgen-deprivation therapy (ADT), with equivalent oncologic efficacy.
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Robert C. Flanigan,Sydney E. Salmon,Brent A. Blumenstein,Scott I. Bearman,Vivek Roy,Patrick C. McGrath,John R. Caton,Nikhil C. Munshi,E. David Crawford +8 more
TL;DR: Nephrectomy followed by interferon therapy results in longer survival among patients with metastatic renal-cell cancer than does interferons therapy alone.
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EAU guidelines on prostate cancer. Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer ☆
Nicolas Mottet,Joaquim Bellmunt,Michel Bolla,Steven Joniau,Malcolm David Mason,Vsevolod Matveev,Hans-Peter Schmid,Theo van der Kwast,Thomas Wiegel,Filiberto Zattoni,Axel Heidenreich +10 more
TL;DR: A summary of the 2010 version of the EAU guidelines on the treatment of advanced, relapsing, and castration-resistant prostate cancer (CRPC) summarise the most recent findings and put them into clinical practice.
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Tumor self-seeding by circulating cancer cells
Miyoung Kim,Thordur Oskarsson,Swarnali Acharyya,Don X. Nguyen,Xiang Zhang,Larry Norton,Joan Massagué +6 more
TL;DR: Tumor self-seeding could explain the relationships between anaplasia, tumor size, vascularity and prognosis, and local recurrence seeded by disseminated cells following ostensibly complete tumor excision.
Journal ArticleDOI
Androgen Deprivation Therapy for Prostate Cancer
TL;DR: Androgen deprivation therapy has clear roles in the management of advanced prostate cancer and high-risk localized disease and the benefits of ADT in other settings need to be weighed carefully against substantial risks and adverse effects on quality of life.
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